KEGG   ENZYME: 3.4.21.117Help
Entry
EC 3.4.21.117               Enzyme                                 

Name
stratum corneum chymotryptic enzyme;
kallikrein 7;
SCCE;
KLK7;
PRSS6;
hK7
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of proteins with aromatic side chains in the P1 position
Comment
This enzyme has wide substrate specificity, being able to degrade heat-denatured bovine casein and the alpha-chain of native human fibrinogen. It cleaves the B chain of bovine insulin at Leu6!Cya7, Tyr16!Leu17, Phe25!Tyr26 and Tyr26!Thr27 [1]. It is thought to play a role in the desquamation (skin-shedding) of the outer layer of skin, the stratum corneum, by degrading intercellular cohesive structures [1,2]. Belongs in peptidase family S1A.
History
EC 3.4.21.117 created 2006
Orthology
K08668  
kallikrein 7
Genes
HSA: 
5650(KLK7)
PTR: 
468973(KLK7)
PPS: 
100970185(KLK8)
GGO: 
101148068(KLK7)
PON: 
100173841(KLK7)
MCC: 
722683(KLK7)
MCF: 
102134711(KLK7)
CSAB: 
103235545(KLK7)
RRO: 
104667248(KLK7)
CJC: 
103790022(KLK7)
SBQ: 
101047010(KLK7)
MMU: 
23993(Klk7)
RNO: 
292852(Klk7)
CGE: 
100753553(Klk7)
NGI: 
103743766(Klk7)
HGL: 
101705516(Klk7)
OCU: 
100343784(KLK7)
TUP: 
102467699(KLK7)
CFA: 
611780(KLK7)
AML: 
100476432(KLK7)
UMR: 
103657286(KLK7)
FCA: 
101088894(KLK7)
PTG: 
102964470(KLK7)
BTA: 
506380(KLK7)
BOM: 
102282184(KLK7)
PHD: 
102315895(KLK7)
CHX: 
102178562(KLK7)
OAS: 
101115562(KLK7)
SSC: 
100359349(KLK7)
BACU: 
102998157(KLK7)
LVE: 
103070574(KLK7)
ECB: 
100146194(KLK7)
MYB: 
MYD: 
PALE: 
102897729(KLK7)
LAV: 
100666907(KLK7)
MDO: 
100012470(KLK7)
SHR: 
 » show all
Taxonomy
Reference
1  [PMID:7794273]
  Authors
Skytt A, Stromqvist M, Egelrud T.
  Title
Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme.
  Journal
Biochem. Biophys. Res. Commun. 211 (1995) 586-9.
  Sequence
[hsa:5650]
Reference
2  [PMID:8393902]
  Authors
Egelrud T.
  Title
Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation.
  Journal
J. Invest. Dermatol. 101 (1993) 200-4.
Reference
3  [PMID:8034709]
  Authors
Hansson L, Stromqvist M, Backman A, Wallbrandt P, Carlstein A, Egelrud T.
  Title
Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase.
  Journal
J. Biol. Chem. 269 (1994) 19420-6.
  Sequence
[hsa:5650]
Reference
4  [PMID:10974542]
  Authors
Yousef GM, Scorilas A, Magklara A, Soosaipillai A, Diamandis EP.
  Title
The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation.
  Journal
Gene. 254 (2000) 119-28.
  Sequence
[hsa:5650]
Reference
5  [PMID:15191543]
  Authors
Vasilopoulos Y, Cork MJ, Murphy R, Williams HC, Robinson DA, Duff GW, Ward SJ, Tazi-Ahnini R.
  Title
Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis.
  Journal
J. Invest. Dermatol. 123 (2004) 62-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
155215-90-0

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