KEGG   ENZYME: 3.4.21.119Help
Entry
EC 3.4.21.119               Enzyme                                 

Name
kallikrein 13;
KLK13;
kallikrein mK13;
mGK-13;
mK13;
mKLK13;
prorenin converting enzyme 1;
PRECE-1;
prorenin-converting enzyme;
PRECE;
proteinase P
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg! pair in the N-terminus, to yield mature renin
Comment
The enzyme is specific for prorenin from the mouse submandibular gland, as prorenin from the mouse kidney (Ren1) and human prorenin are not substrates [1]. Site-directed mutagenesis studies have shown that the enzyme will also cleave prorenin when Lys-Arg is replaced by Arg-Arg or Gln-Arg but the rate of reaction is much slower when Lys-Lys is used. This enzyme is also able to process pro-interleukin-1beta (pro-IL-1beta) in mouse submandibular gland to form IL-1beta [4]. Belongs in peptidase family S1A.
History
EC 3.4.21.119 created 2006
Orthology
K09462  
glandular kallikrein 13
K09463  
kallikrein 13
Genes
HSA: 
26085(KLK13)
PTR: 
748200(KLK13)
PPS: 
103785249(KLK13)
GGO: 
101150353(KLK13)
PON: 
100438457(KLK13)
NLE: 
100590429(KLK13)
MCC: 
106994830(KLK13)
MCF: 
102147127(KLK13)
RRO: 
104667255(KLK13)
CJC: 
100404986(KLK13)
MMU: 
13647(Egfbp2) 626834(Klk13)
RNO: 
292848(Klk13)
CGE: 
100761429(Klk13)
NGI: 
103743721(Klk13)
HGL: 
101704794(Klk13)
OCU: 
100345308(KLK13)
TUP: 
102490552(KLK13)
CFA: 
100856194(KLK13)
AML: 
100475439(KLK13)
UMR: 
103657290(KLK13)
FCA: 
102902318(KLK13)
PTG: 
102966011(KLK13)
BTA: 
540297(KLK13)
BOM: 
102280496(KLK13)
PHD: 
102317998(KLK13)
CHX: 
102180530(KLK13)
OAS: 
101120106(KLK13)
CFR: 
102520551(KLK13)
BACU: 
102997885(KLK13)
ECB: 
100067063(KLK13)
MYB: 
102245547(KLK13)
MYD: 
102763838(KLK13)
PALE: 
102897491(KLK13)
MDO: 
100028184(KLK13)
SHR: 
100934700(KLK14) 105749001(KLK13)
CLV: 
 » show all
Taxonomy
Reference
1  [PMID:2250008]
  Authors
Nakayama K, Kim WS, Nakagawa T, Nagahama M, Murakami K.
  Title
Substrate specificity of prorenin converting enzyme of mouse submandibular gland. Analysis using site-directed mutagenesis.
  Journal
J. Biol. Chem. 265 (1990) 21027-31.
Reference
2  [PMID:2180937]
  Authors
Kim WS, Hatsuzawa K, Ishizuka Y, Hashiba K, Murakami K, Nakayama K.
  Title
A processing enzyme for prorenin in mouse submandibular gland. Purification and characterization.
  Journal
J. Biol. Chem. 265 (1990) 5930-3.
Reference
3  [PMID:9507064]
  Authors
Kikkawa Y, Yamanaka N, Tada J, Kanamori N, Tsumura K, Hosoi K.
  Title
Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22).
  Journal
Biochim. Biophys. Acta. 1382 (1998) 55-64.
Reference
4  [PMID:16423834]
  Authors
Yao C, Karabasil MR, Purwanti N, Li X, Akamatsu T, Kanamori N, Hosoi K.
  Title
Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice.
  Journal
J. Biol. Chem. 281 (2006) 7968-76.
  Sequence
[mmu:626834]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
342900-44-1

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