KEGG   ENZYME: 3.4.21.120Help
Entry
EC 3.4.21.120               Enzyme                                 

Name
oviductin;
oviductal protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage at Gly-Ser-Arg373! of glycoprotein gp43 in Xenopus laevis coelemic egg envelope to yield gp41
Comment
The egg envelope of the South African clawed frog (Xenopus laevis) is modified during transit of the egg through the pars rectus oviduct, changing the egg envelope from an unfertilizable form to a fertilizable form. This process involves the conversion of glycoprotein gp43 to gp41 (ZPC) by the pars recta protease oviductin. It is thought that the enzymically active protease molecule comprises the N-terminal protease domain coupled to two C-terminal CUB domains, which are related to the mammalian spermadhesin molecules implicated in mediating sperm-envelope interactions [2]. The enzyme is also found in the Japanese toad (Bufo japonicus) [3]. Belongs in peptidase family S1.
History
EC 3.4.21.120 created 2007
Orthology
K20111  
oviductin
Genes
MDO: 
100027745(OVCH2)
SHR: 
OAA: 
100076426(OVCH2)
GGA: 
769290(OVCH2)
MGP: 
100541355(OVCH2)
CJO: 
107314584(OVCH2)
APLA: 
101798316(OVCH2)
TGU: 
FAB: 
101811575(OVCH2)
CCW: 
104692962(OVCH2)
FPG: 
101910452(OVCH2)
FCH: 
102053250(OVCH2)
CLV: 
102088414(OVCH2)
AAM: 
106497080(OVCH2)
ASN: 
102383299(OVCH2)
AMJ: 
PSS: 
CMY: 
102933552(OVCH2)
ACS: 
100566043(ovch2)
PBI: 
103050766(OVCH2)
GJA: 
107111731(OVCH2)
XLA: 
398108(ovch2.S)
XTR: 
100496902(ovch2)
SASA: 
106561585(ovch2)
LCM: 
102365172(OVCH2)
CMK: 
103175111(ovch2)
BFO: 
CRG: 
 » show all
Taxonomy
Reference
1  [PMID:1581303]
  Authors
Hardy DM, Hedrick JL.
  Title
Oviductin. Purification and properties of the oviductal protease that processes the molecular weight 43,000 glycoprotein of the Xenopus laevis egg envelope.
  Journal
Biochemistry. 31 (1992) 4466-72.
Reference
2  [PMID:10084976]
  Authors
Lindsay LL, Wieduwilt MJ, Hedrick JL.
  Title
Oviductin, the Xenopus laevis oviductal protease that processes egg envelope glycoprotein gp43, increases sperm binding to envelopes, and is translated as part of an unusual mosaic protein composed of two protease and several CUB domains.
  Journal
Biol. Reprod. 60 (1999) 989-95.
  Sequence
[xla:398108]
Reference
3  [PMID:11846486]
  Authors
Hiyoshi M, Takamune K, Mita K, Kubo H, Sugimoto Y, Katagiri C.
  Title
Oviductin, the oviductal protease that mediates gamete interaction by affecting the vitelline coat in Bufo japonicus: its molecular cloning and analyses of expression and posttranslational activation.
  Journal
Dev. Biol. 243 (2002) 176-84.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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