KEGG   ENZYME: 3.4.21.121Help
Entry
EC 3.4.21.121               Enzyme                                 

Name
Lys-Lys/Arg-Xaa endopeptidase;
ASP (Aeromonas sobria)-type peptidase;
Aeromonas extracellular serine protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of -Lys-Lys! and -Lys-Arg! bonds.
Comment
The enzyme is a serine peptidase, which has been shown to cleave prothrombin and prekallikrein. It hydrolyses the complement component C5 releasing complement component C5a.
History
EC 3.4.21.121 created 2013
Reference
1  [PMID:19654332]
  Authors
Kobayashi H, Utsunomiya H, Yamanaka H, Sei Y, Katunuma N, Okamoto K, Tsuge H
  Title
Structural basis for the kexin-like serine protease from Aeromonas sobria as sepsis-causing factor.
  Journal
J. Biol. Chem. 284 (2009) 27655-63.
  Sequence
Reference
2  [PMID:18067862]
  Authors
Nitta H, Kobayashi H, Irie A, Baba H, Okamoto K, Imamura T
  Title
Activation of prothrombin by ASP, a serine protease released from Aeromonas sobria.
  Journal
FEBS. Lett. 581 (2007) 5935-9.
Reference
3  [PMID:16487335]
  Authors
Kobayashi H, Takahashi E, Oguma K, Fujii Y, Yamanaka H, Negishi T, Arimoto-Kobayashi S, Tsuji T, Okamoto K
  Title
Cleavage specificity of the serine protease of Aeromonas sobria, a member of the  kexin family of subtilases.
  Journal
FEMS. Microbiol. Lett. 256 (2006) 165-70.
Reference
4  [PMID:18462393]
  Authors
Imamura T, Nitta H, Wada Y, Kobayashi H, Okamoto K
  Title
Impaired plasma clottability induction through fibrinogen degradation by ASP, a serine protease released from Aeromonas sobria.
  Journal
FEMS. Microbiol. Lett. 284 (2008) 35-42.
Reference
5  [PMID:18714034]
  Authors
Nitta H, Imamura T, Wada Y, Irie A, Kobayashi H, Okamoto K, Baba H
  Title
Production of C5a by ASP, a serine protease released from Aeromonas sobria.
  Journal
J. Immunol. 181 (2008) 3602-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system