KEGG   ENZYME: 3.4.21.36Help
Entry
EC 3.4.21.36                Enzyme                                 

Name
pancreatic elastase;
pancreatopeptidase E;
pancreatic elastase I;
elastase;
elaszym;
serine elastase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins, including elastin. Preferential cleavage: Ala!
Comment
Formed by activation of proelastase from mammalian pancreas by trypsin. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11
History
EC 3.4.21.36 created 1981 (EC 3.4.4.7 created 1961, transferred 1972 to EC 3.4.21.11 created 1972, part incorporated 1984)
Orthology
K01326  
pancreatic elastase I
Genes
HSA: 
1990(CELA1)
PTR: 
740437(CELA1)
PPS: 
100976646(CELA1)
GGO: 
101143430(CELA1)
PON: 
100450522(CELA1)
NLE: 
100582065(CELA1)
MCC: 
695507(CELA1)
MCF: 
102139348(CELA1)
CSAB: 
103238322(CELA1)
RRO: 
104670677(CELA1)
CJC: 
100390402(CELA1)
SBQ: 
101036476(CELA1)
MMU: 
109901(Cela1)
RNO: 
24331(Cela1)
CGE: 
NGI: 
103739592(Cela1)
HGL: 
101715061(Cela1)
OCU: 
100348556(CELA1)
TUP: 
102501966(CELA1)
CFA: 
403515(CELA1)
AML: 
100477910(CELA1)
UMR: 
103675492(CELA1)
FCA: 
494217(CELA1)
PTG: 
102970463(CELA1)
BTA: 
281139(CELA1)
BOM: 
102265097(CELA1)
PHD: 
102334821(CELA1)
CHX: 
102187460(CELA1)
OAS: 
101114258(CELA1)
SSC: 
396766(CELA1)
CFR: 
102517832(CELA1)
BACU: 
103016249(CELA1)
LVE: 
103073295(CELA1)
ECB: 
100052672(CELA1)
MYB: 
102247948(CELA1)
MYD: 
102768502(CELA1)
PALE: 
102894029(CELA1)
LAV: 
100676855(CELA1)
SHR: 
100934635(CELA1)
GGA: 
425200(CELA1)
MGP: 
100543650(CELA1)
CJO: 
107325771(CELA1)
APLA: 
101796072(CELA1)
TGU: 
100221837(CELA1)
FAB: 
101814575(CELA1)
PHI: 
CCW: 
104683700(CELA1)
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
ACS: 
100567701(cela1)
PBI: 
103057004(CELA1)
GJA: 
XLA: 
398300(cela1)
XTR: 
DRE: 
445032(fb62f03) 445282
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
CMK: 
103189977(cela1)
BFO: 
 » show all
Taxonomy
Reference
1
  Authors
Shotton, D.M.
  Title
Elastase.
  Journal
Methods Enzymol. 19 (1970) 113-140.
Reference
2  [PMID:6380580]
  Authors
Harper JW, Cook RR, Roberts CJ, McLaughlin BJ, Powers JC.
  Title
Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates.
  Journal
Biochemistry. 23 (1984) 2995-3002.
Reference
3  [PMID:3646943]
  Authors
Kawashima I, Tani T, Shimoda K, Takiguchi Y.
  Title
Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.
  Journal
DNA. 6 (1987) 163-72.
Reference
4  [PMID:2909256]
  Authors
Bieth JG, Dirrig S, Jung ML, Boudier C, Papamichael E, Sakarellos C, Dimicoli JL.
  Title
Investigation of the active center of rat pancreatic elastase.
  Journal
Biochim. Biophys. Acta. 994 (1989) 64-74.
Reference
5  [PMID:2655701]
  Authors
Bode W, Meyer E Jr, Powers JC.
  Title
Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.
  Journal
Biochemistry. 28 (1989) 1951-63.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9004-06-2

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