KEGG   ENZYME: 3.4.21.42Help
Entry
EC 3.4.21.42                Enzyme                                 
Name
complement subcomponent C_overbar_1s_;
C1 esterase;
activated complement C1s;
complement C_overbar_1r_
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of Arg!Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)!Lys bond in complement component C2 to form C2a and C2b: the "classical" pathway C3 convertase
Comment
Activated from proenzyme C1s in plasma by complement subcomponent C_overbar_1r_. In peptidase family S1 (trypsin family)
Orthology
K01331  
complement component 1, s subcomponent
Genes
HSA: 
716(C1S)
PTR: 
451808(C1S)
PPS: 
GGO: 
PON: 
MCC: 
714589(C1S)
MMU: 
317677(Gm5077) 50908(C1s)
RNO: 
192262(C1s)
CFA: 
486714(C1S)
AML: 
FCA: 
101088676(C1S)
BTA: 
767827(C1S)
SSC: 
397274(C1S)
ECB: 
100060261
MDO: 
100016766
SHR: 
100917190(C1S)
OAA: 
100085003
GGA: 
418294(C1S)
MGP: 
100549400(C1S)
TGU: 
100222051(C1S)
ACS: 
100558615(c1s)
XLA: 
733422(c1s)
XTR: 
613055(c1s)
OLA: 
101170617
 » show all
Taxonomy
Reference
1  [PMID:6281620]
  Authors
Sim RB.
  Title
The human complement system serine proteases C1r and C1s and their proenzymes.
  Journal
Methods. Enzymol. 80 Pt C (1981) 26-42.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:3500856]
  Authors
Mackinnon CM, Carter PE, Smyth SJ, Dunbar B, Fothergill JE.
  Title
Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence.
  Journal
Eur. J. Biochem. 169 (1987) 547-53.
  Organism
Homo sapiens [GN:hsa]
  Sequence
HSA: 716
Reference
3  [PMID:3052276]
  Authors
Muller-Eberhard HJ.
  Title
Molecular organization and function of the complement system.
  Journal
Annu. Rev. Biochem. 57 (1988) 321-47.
  Organism
Homo sapiens [GN:hsa]
Reference
4  [PMID:2500154]
  Authors
Skoog MT, Mehdi S, Wiseman JS, Bey P.
  Title
The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates.
  Journal
Biochim. Biophys. Acta. 996 (1989) 89-94.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
80295-70-1
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