KEGG   ENZYME: 3.4.21.46Help
Entry
EC 3.4.21.46                Enzyme                                 

Name
complement factor D;
C3 proactivator convertase;
properdin factor D esterase;
factor D;
factor D (complement)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Arg!Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor
Comment
A component of the alternative pathway of complement activation. This reaction is analogous to the activation of complement component C2 by complement subcomponent C_overbar_1s_. In peptidase family S1 (trypsin family)
History
EC 3.4.21.46 created 1981
Orthology
K01334  
component factor D
Genes
HSA: 
1675(CFD)
PTR: 
455533(CFD)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
721138(CFD)
MCF: 
CSAB: 
RRO: 
CJC: 
SBQ: 
MMU: 
11537(Cfd)
RNO: 
54249(Cfd)
CGE: 
NGI: 
HGL: 
TUP: 
CFA: 
485095(CFD)
AML: 
FCA: 
BTA: 
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
396877(CFD)
CFR: 
LVE: 
MYD: 
PALE: 
LAV: 
SHR: 
OAA: 
791100(CFD)
GGA: 
MGP: 
CJO: 
TGU: 
GFR: 
FAB: 
PHI: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
CMY: 
PBI: 
GJA: 
XLA: 
494791(cfd.L)
XTR: 
394945(cfd)
DRE: 
553553(cfd)
TRU: 
TNG: 
MZE: 
OLA: 
100049308(olklklp)
XMA: 
SASA: 
 » show all
Taxonomy
Reference
1  [PMID:6918766]
  Authors
Reid KB, Johnson DM, Gagnon J, Phohaska R.
  Title
Preparation of human factor D of the alternative pathway of complement.
  Journal
Methods. Enzymol. 80 Pt C (1981) 134-43.
Reference
2  [PMID:3052276]
  Authors
Muller-Eberhard HJ.
  Title
Molecular organization and function of the complement system.
  Journal
Annu. Rev. Biochem. 57 (1988) 321-47.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37213-56-2

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