KEGG   ENZYME: 3.4.21.48Help
Entry
EC 3.4.21.48                Enzyme                                 

Name
cerevisin;
yeast proteinase B;
proteinase yscB;
baker's yeast proteinase B;
brewer's yeast proteinase;
peptidase beta
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins with broad specificity, and of Bz-Arg-OEt Ac-Tyr-OEt. Does not hydrolyse peptide amides
Comment
From Saccharomyces cerevisiae (baker's yeast, brewer's yeast). In peptidase family S8 (subtilisin family), but contains a Cys residue near the active site His, and is inhibited by mercurials. Proteinase ycaB is a similar enzyme from the yeast Candida albicans [3]
History
EC 3.4.21.48 created 1972 as EC 3.4.22.9, transferred 1981 to EC 3.4.21.48
Orthology
K01336  cerevisin
Genes
BFO: BRAFLDRAFT_118415 BRAFLDRAFT_121465
SKO: 100366912 100367213 102803900
LAK: 106151688 106153601 106163865 106165961 106168269 106168272 106177170
AQU: 100636066 100641796
SCE: YEL060C(PRB1) YOR003W(YSP3)
AGO: AGOS_ACR012C
ERC: Ecym_3018
KLA: KLLA0D00979g
KMX: KLMA_80029(PRB1)
LTH: KLTH0C11396g
NCS: NCAS_0D02630(NCAS0D02630) NCAS_0F00220(NCAS0F00220)
NDI: NDAI_0I02280(NDAI0I02280) NDAI_0K02880(NDAI0K02880)
TPF: TPHA_0M00230(TPHA0M00230)
TBL: TBLA_0A07300(TBLA0A07300)
TDL: TDEL_0G04550(TDEL0G04550)
KAF: KAFR_0B06550(KAFR0B06550) KAFR_0L00360(KAFR0L00360)
CAL: CAALFM_C206880CA(PRB1) CAALFM_C703860WA(CaO19.7196)
CDU: CD36_21180(ScPRB1) CD36_73550
SLB: AWJ20_1267(PRB1) AWJ20_3627(PRB1)
NCR: NCU00673
NTE: NEUTE1DRAFT118570(NEUTE1DRAFT_118570)
MGR: MGG_03670
MAW: MAC_04385
MAJ: MAA_10260
CMT: CCM_01138
MBE: MBM_07519
ANI: AN0238.2
ANG: ANI_1_476064(An07g03880)
CIM: CIMG_13072(CIMG06672)
ABE: ARB_00777
TVE: TRV_07778
PNO: SNOG_14851(SNOG_14850) SNOG_16555
SPO: SPAC1006.01(psp3) SPAC4A8.04(isp6)
CNB: CNBJ2870
ABP: AGABI1DRAFT112911(AGABI1DRAFT_112911)
ABV: AGABI2DRAFT192881(AGABI2DRAFT_192881)
 » show all
Taxonomy
Reference
1  [PMID:4961236]
  Authors
Felix F, Brouillet N.
  Title
[Purification and properties of 2 peptidases from baker's yeast]
  Journal
Biochim. Biophys. Acta. 122 (1966) 127-44.
Reference
2  [PMID:7028121]
  Authors
Kominami E, Hoffschulte H, Leuschel L, Maier K, Holzer H.
  Title
The substrate specificity of proteinase B from baker's yeast.
  Journal
Biochim. Biophys. Acta. 661 (1981) 136-41.
Reference
3  [PMID:3539100]
  Authors
Farley PC, Shepherd MG, Sullivan PA.
  Title
The purification and properties of yeast proteinase B from Candida albicans.
  Journal
Biochem. J. 236 (1986) 177-84.
Reference
4  [PMID:3325823]
  Authors
Moehle CM, Tizard R, Lemmon SK, Smart J, Jones EW.
  Title
Protease B of the lysosomelike vacuole of the yeast Saccharomyces cerevisiae is homologous to the subtilisin family of serine proteases.
  Journal
Mol. Cell. Biol. 7 (1987) 4390-9.
  Sequence
[sce:YEL060C]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.48
IUBMB Enzyme Nomenclature: 3.4.21.48
ExPASy - ENZYME nomenclature database: 3.4.21.48
BRENDA, the Enzyme Database: 3.4.21.48
CAS: 37288-81-6

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