KEGG   ENZYME: 3.4.21.48Help
Entry
EC 3.4.21.48                Enzyme                                 

Name
cerevisin;
yeast proteinase B;
proteinase yscB;
baker's yeast proteinase B;
brewer's yeast proteinase;
peptidase beta
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins with broad specificity, and of Bz-Arg-OEt Ac-Tyr-OEt. Does not hydrolyse peptide amides
Comment
From Saccharomyces cerevisiae (baker's yeast, brewer's yeast). In peptidase family S8 (subtilisin family), but contains a Cys residue near the active site His, and is inhibited by mercurials. Proteinase ycaB is a similar enzyme from the yeast Candida albicans [3]
History
EC 3.4.21.48 created 1972 as EC 3.4.22.9, transferred 1981 to EC 3.4.21.48
Orthology
K01336  
cerevisin
Genes
BFO: 
SKO: 
AQU: 
SCE: 
YEL060C(PRB1) YOR003W(YSP3)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0D02630(NCAS0D02630) NCAS_0F00220(NCAS0F00220)
NDI: 
NDAI_0I02280(NDAI0I02280) NDAI_0K02880(NDAI0K02880)
TPF: 
TPHA_0M00230(TPHA0M00230)
TBL: 
TBLA_0A07300(TBLA0A07300)
TDL: 
TDEL_0G04550(TDEL0G04550)
KAF: 
KAFR_0B06550(KAFR0B06550) KAFR_0L00360(KAFR0L00360)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CaO19.2242(PRB11) CaO19.7196(PRB12) CaO19.9783(PRB11) CaO19_7196(CaJ7_0441)
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NTE: 
NEUTE1DRAFT118570(NEUTE1DRAFT_118570)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_902084(AO090020000517)
ANG: 
ANI_1_476064(An07g03880)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CIMG_13072(CIMG06672)
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
SPO: 
CNB: 
CGI: 
TMS: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT112911(AGABI1DRAFT_112911) AGABI1DRAFT130896(AGABI1DRAFT_130896) AGABI1DRAFT130898(AGABI1DRAFT_130898)
ABV: 
AGABI2DRAFT120846(AGABI2DRAFT_120846) AGABI2DRAFT192881(AGABI2DRAFT_192881)
CPUT: 
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
PGR: 
MLR: 
ECU: 
EIN: 
EHE: 
ERO: 
NCE: 
 » show all
Taxonomy
Reference
1  [PMID:4961236]
  Authors
Felix F, Brouillet N.
  Title
[Purification and properties of 2 peptidases from baker's yeast]
  Journal
Biochim. Biophys. Acta. 122 (1966) 127-44.
Reference
2  [PMID:7028121]
  Authors
Kominami E, Hoffschulte H, Leuschel L, Maier K, Holzer H.
  Title
The substrate specificity of proteinase B from baker's yeast.
  Journal
Biochim. Biophys. Acta. 661 (1981) 136-41.
Reference
3  [PMID:3539100]
  Authors
Farley PC, Shepherd MG, Sullivan PA.
  Title
The purification and properties of yeast proteinase B from Candida albicans.
  Journal
Biochem. J. 236 (1986) 177-84.
Reference
4  [PMID:3325823]
  Authors
Moehle CM, Tizard R, Lemmon SK, Smart J, Jones EW.
  Title
Protease B of the lysosomelike vacuole of the yeast Saccharomyces cerevisiae is homologous to the subtilisin family of serine proteases.
  Journal
Mol. Cell. Biol. 7 (1987) 4390-9.
  Sequence
[sce:YEL060C]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37288-81-6

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