KEGG   ENZYME: 3.4.21.49Help
Entry
EC 3.4.21.49                Enzyme                                 

Name
hypodermin C;
Hypoderma collagenase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins including native collagen at !Ala bond leaving an N-terminal (75%) and a C-terminal (25%) fragment
Comment
From the larva of a warble fly, Hypoderma lineatum. Little action on small molecule substrates of trypsin, chymotrypsin, elastase or microbial collagenases. In peptidase family S1 (trypsin family)
History
EC 3.4.21.49 created 1981
Orthology
K20752  hypodermin C
Genes
DME: Dmel_CG6467(Jon65Aiv)
DPO: Dpse_GA19618
DAN: Dana_GF10666
DER: Dere_GG15307
DPE: Dper_GL15536 Dper_GL15537
DSE: Dsec_GM14741
DSI: Dsimw501_GD10590(Dsim_GD10590) Dsimw501_GD13922(Dsim_GD13922)
DWI: Dwil_GK16888
DYA: Dyak_GE21528
DGR: Dgri_GH15022
DPA: 109537073
ZNE: 110834180
 » show all
Taxonomy
Reference
1  [PMID:230030]
  Authors
Lecroisey A, Boulard C, Keil B.
  Title
Chemical and enzymatic characterization of the collagenase from the insect Hypoderma lineatum.
  Journal
Eur. J. Biochem. 101 (1979) 385-93.
  Sequence
Reference
2  [PMID:2995028]
  Authors
Lecroisey A, Keil B.
  Title
Specificity of the collagenase from the insect Hypoderma lineatum.
  Journal
Eur. J. Biochem. 152 (1985) 123-30.
  Sequence
Reference
3  [PMID:3034899]
  Authors
Lecroisey A, Gilles AM, De Wolf A, Keil B.
  Title
Complete amino acid sequence of the collagenase from the insect Hypoderma lineatum.
  Journal
J. Biol. Chem. 262 (1987) 7546-51.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.49
IUBMB Enzyme Nomenclature: 3.4.21.49
ExPASy - ENZYME nomenclature database: 3.4.21.49
BRENDA, the Enzyme Database: 3.4.21.49
CAS: 122191-36-0

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