KEGG   ENZYME: 3.4.21.50Help
Entry
EC 3.4.21.50                Enzyme                                 

Name
lysyl endopeptidase;
Achromobacter proteinase I (also see Comment);
Achromobacter lyticus alkaline proteinase I;
protease I;
achromopeptidase;
lysyl bond specific proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Lys!, including -Lys!Pro-
Comment
From Achromobacter lyticus [6]. Enzymes with similar specificity are produced by Lysobacter enzymogenes (Endoproteinase Lys-C; [3]) and Pseudomonas aeruginosa (Ps-1; [4]). In peptidase family S1 (trypsin family)
History
EC 3.4.21.50 created 1983
Orthology
K01337  
lysyl endopeptidase
Genes
LAB: 
LCP: 
LGU: 
LEZ: 
SWD: 
WMA: 
HAU: 
SRU: 
SRM: 
SRM_01822(prpL)
HHY: 
SGN: 
FTE: 
 » show all
Taxonomy
Reference
1  [PMID:6791693]
  Authors
Masaki T, Tanabe M, Nakamura K, Soejima M.
  Title
Studies on a new proteolytic enzyme from A chromobacter lyticus M497-1. I. Purification and some enzymatic properties.
  Journal
Biochim. Biophys. Acta. 660 (1981) 44-50.
Reference
2  [PMID:6168293]
  Authors
Masaki T, Fujihashi T, Nakamura K, Soejima M.
  Title
Studies on a new proteolytic enzyme from Achromobacter lyticus M497-1. II. specificity and inhibition studies of Achromobacter protease I.
  Journal
Biochim. Biophys. Acta. 660 (1981) 51-5.
Reference
3  [PMID:6359954]
  Authors
Jekel PA, Weijer WJ, Beintema JJ.
  Title
Use of endoproteinase Lys-C from Lysobacter enzymogenes in protein sequence analysis.
  Journal
Anal. Biochem. 134 (1983) 347-54.
Reference
4  [PMID:3090046]
  Authors
Elliott BW Jr, Cohen C.
  Title
Isolation and characterization of a lysine-specific protease from Pseudomonas aeruginosa.
  Journal
J. Biol. Chem. 261 (1986) 11259-65.
Reference
5  [PMID:2684982]
  Authors
Ohara T, Makino K, Shinagawa H, Nakata A, Norioka S, Sakiyama F.
  Title
Cloning, nucleotide sequence, and expression of Achromobacter protease I gene.
  Journal
J. Biol. Chem. 264 (1989) 20625-31.
  Sequence
Reference
6  [PMID:2492988]
  Authors
Tsunasawa S, Masaki T, Hirose M, Soejima M, Sakiyama F.
  Title
The primary structure and structural characteristics of Achromobacter lyticus protease I, a lysine-specific serine protease.
  Journal
J. Biol. Chem. 264 (1989) 3832-9.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
123175-82-6

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