KEGG   ENZYME: 3.4.21.54Help
Entry
EC 3.4.21.54                Enzyme                                 

Name
gamma-renin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of the Leu!Leu bond in synthetic tetradecapeptide renin substrate (horse), to produce angiotensin I, but not active on natural angiotensinogen, unlike renin (EC 3.4.23.15). Also hydrolyses Bz-Arg-p-nitroanilide
Comment
A member of the tissue kallikrein family, from submandibular glands of male mice. In peptidase family S1 (trypsin family)
History
EC 3.4.21.54 created 1986
Orthology
K01339  
g-renin
Genes
MMU: 
16615(Klk1b16)
Taxonomy
Reference
1  [PMID:6337154]
  Authors
Poe M, Wu JK, Florance JR, Rodkey JA, Bennett CD, Hoogsteen K.
  Title
Purification and properties of renin and gamma-renin from the mouse submaxillary gland.
  Journal
J. Biol. Chem. 258 (1983) 2209-16.
  Sequence
[mmu:16615]
Reference
2  [PMID:3288617]
  Authors
Drinkwater CC, Evans BA, Richards RI.
  Title
Sequence and expression of mouse gamma-renin.
  Journal
J. Biol. Chem. 263 (1988) 8565-8.
  Sequence
[mmu:16615]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
85270-20-8

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