KEGG   ENZYME: 3.4.21.61Help
Entry
EC 3.4.21.61                Enzyme                                 

Name
kexin;
yeast KEX2 protease;
proteinase yscF;
prohormone-processing endoprotease;
paired-basic endopeptidase;
yeast cysteine proteinase F (misleading);
paired-basic endopeptidase;
andrenorphin-Gly-generating enzyme;
endoproteinase Kex2p;
gene KEX2 dibasic proteinase;
Kex 2p proteinase;
Kex2 endopeptidase;
Kex2 endoprotease;
Kex2 endoproteinase;
Kex2 protease;
proteinase Kex2p;
Kex2-like precursor protein processing endoprotease;
prohormone-processing KEX2 proteinase;
prohormone-processing proteinase;
proprotein convertase;
protease KEX2;
Kex2 proteinase;
Kex2-like endoproteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of -Lys-Arg! and -Arg-Arg! bonds to process yeast alpha-factor pheromone and killer toxin precursors
Comment
A Ca2+-activated peptidase of peptidase family S8, containing Cys near the active site His, and inhibited by p-mercuribenzoate. Similar enzymes occur in mammals.
History
EC 3.4.21.61 created 1989 as EC 3.4.22.23, transferred 1992 to EC 3.4.21.61
Orthology
K01341  
kexin
Genes
SCE: 
YNL238W(KEX2)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A00880(NCAS0A00880)
NDI: 
NDAI_0F03890(NDAI0F03890)
TPF: 
TPHA_0P01790(TPHA0P01790)
TBL: 
TBLA_0B00130(TBLA0B00130)
TDL: 
TDEL_0E00410(TDEL0E00410)
KAF: 
KAFR_0A08040(KAFR0A08040)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
NTE: 
NEUTE1DRAFT133220(NEUTE1DRAFT_133220)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_472184(AO090009000291)
ANG: 
ANI_1_1140014(An01g08530)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT52884(AGABI1DRAFT_52884)
ABV: 
AGABI2DRAFT199236(AGABI2DRAFT_199236)
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
AAF: 
EHX: 
DAF: 
 » show all
Taxonomy
Reference
1  [PMID:6430565]
  Authors
Julius D, Brake A, Blair L, Kunisawa R, Thorner J.
  Title
Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor.
  Journal
Cell. 37 (1984) 1075-89.
Reference
2  [PMID:3894003]
  Authors
Achstetter T, Wolf DH.
  Title
Hormone processing and membrane-bound proteinases in yeast.
  Journal
EMBO. J. 4 (1985) 173-7.
Reference
3  [PMID:2845974]
  Authors
Mizuno K, Nakamura T, Ohshima T, Tanaka S, Matsuo H.
  Title
Yeast KEX2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases.
  Journal
Biochem. Biophys. Res. Commun. 156 (1988) 246-54.
  Sequence
[sce:YNL238W]
Reference
4  [PMID:2646633]
  Authors
Fuller RS, Brake A, Thorner J.
  Title
Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 1434-8.
  Sequence
[sce:YNL238W]
Reference
5  [PMID:2647083]
  Authors
Mizuno K, Nakamura T, Ohshima T, Tanaka S, Matsuo H
  Title
Characterization of KEX2-encoded endopeptidase from yeast Saccharomyces cerevisiae.
  Journal
Biochem. Biophys. Res. Commun. 159 (1989) 305-11.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
99676-46-7

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