KEGG   ENZYME: 3.4.21.61Help
Entry
EC 3.4.21.61                Enzyme                                 
Name
kexin;
yeast KEX2 protease;
proteinase yscF;
prohormone-processing endoprotease;
paired-basic endopeptidase;
yeast cysteine proteinase F (misleading);
paired-basic endopeptidase;
andrenorphin-Gly-generating enzyme;
endoproteinase Kex2p;
gene KEX2 dibasic proteinase;
Kex 2p proteinase;
Kex2 endopeptidase;
Kex2 endoprotease;
Kex2 endoproteinase;
Kex2 protease;
proteinase Kex2p;
Kex2-like precursor protein processing endoprotease;
prohormone-processing KEX2 proteinase;
prohormone-processing proteinase;
proprotein convertase;
protease KEX2;
Kex2 proteinase;
Kex2-like endoproteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of -Lys-Arg! and -Arg-Arg! bonds to process yeast alpha-factor pheromone and killer toxin precursors
Comment
A Ca2+-activated peptidase of peptidase family S8, containing Cys near the active site His, and inhibited by p-mercuribenzoate. Similar enzymes occur in mammals.
Orthology
K01341  
kexin
Genes
SCE: 
YNL238W(KEX2)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A00880(NCAS0A00880)
NDI: 
NDAI_0F03890(NDAI0F03890)
TPF: 
TPHA_0P01790(TPHA0P01790)
TBL: 
TBLA_0B00130(TBLA0B00130)
TDL: 
TDEL_0E00410(TDEL0E00410)
KAF: 
KAFR_0A08040(KAFR0A08040)
DHA: 
DEHA2C10296g
PIC: 
PICST_14973
PGU: 
PGUG_03723
LEL: 
LELG_00316
CAL: 
CaO19.12219(KEX2) CaO19.4755(KEX2)
CTP: 
CTRG_03249
CDU: 
CD36_08480
COT: 
CORT_0A01670
YLI: 
YALI0F13189g
CLU: 
CLUG_01869
NCR: 
NCU03219
SMP: 
SMAC_02938
PAN: 
PODANSg09433
TTT: 
THITE_2120746
MTM: 
MYCTH_2293998
FGR: 
FG09156.1
NHE: 
NECHADRAFT_96635
VAL: 
VDBG_03817
SSL: 
SS1G_06027
BFU: 
BC1G_01499
ANI: 
AN3583.2
NFI: 
NFIA_103380
AFM: 
AFUA_4G12970
AOR: 
AOR_1_472184(AO090009000291)
ANG: 
ANI_1_1140014(An01g08530)
AFV: 
AFLA_051750
ACT: 
ACLA_051950
PCS: 
Pc22g02910
CIM: 
CIMG_00625
CPW: 
CPC735_056300
PBL: 
PAAG_07022
URE: 
UREG_00628
ABE: 
ARB_00131
TVE: 
TRV_06672
AJE: 
HCAG_07015
PNO: 
SNOG_04420
PTE: 
PTT_12023
ZTR: 
MYCGRDRAFT_10819(MgSPR2)
TML: 
GSTUM_00008707001
SPO: 
SPAC22E12.09c(krp1)
CNE: 
CNH01120
CNB: 
CNBL1060
CGI: 
CGB_L1170W
LBC: 
LACBIDRAFT_248825 LACBIDRAFT_322240
MPR: 
MPER_05077
CCI: 
CC1G_12012
SCM: 
SCHCODRAFT_65424
UMA: 
UM02843.1
MGL: 
MGL_3817
PGR: 
PGTG_08683
 » show all
Taxonomy
Reference
1  [PMID:6430565]
  Authors
Julius D, Brake A, Blair L, Kunisawa R, Thorner J.
  Title
Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor.
  Journal
Cell. 37 (1984) 1075-89.
  Organism
Saccharomyces cerevisiae [GN:sce]
Reference
2  [PMID:3894003]
  Authors
Achstetter T, Wolf DH.
  Title
Hormone processing and membrane-bound proteinases in yeast.
  Journal
EMBO. J. 4 (1985) 173-7.
  Organism
Saccharomyces cerevisiae [GN:sce]
Reference
3  [PMID:2845974]
  Authors
Mizuno K, Nakamura T, Ohshima T, Tanaka S, Matsuo H.
  Title
Yeast KEX2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases.
  Journal
Biochem. Biophys. Res. Commun. 156 (1988) 246-54.
  Organism
Saccharomyces cerevisiae [GN:sce]
  Sequence
NCBI-GI: 531007
Reference
4  [PMID:2646633]
  Authors
Fuller RS, Brake A, Thorner J.
  Title
Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 1434-8.
  Organism
Saccharomyces cerevisiae [GN:sce]
Reference
5  [PMID:2845974]
  Authors
Mizuno K, Nakamura T, Ohshima T, Tanaka S, Matsuo H.
  Title
Yeast KEX2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases.
  Journal
Biochem. Biophys. Res. Commun. 156 (1988) 246-54.
  Organism
Saccharomyces cerevisiae [GN:sce]
  Sequence
NCBI-GI: 531007
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
99676-46-7
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