KEGG   ENZYME: 3.4.21.66Help
Entry
EC 3.4.21.66                Enzyme                                 

Name
thermitase;
thermophilic Streptomyces serine proteinase;
Thermoactinomyces vulgaris serine proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins, including collagen
Comment
A peptidase of family S8 (subtilisin family) from Thermoactinomyces vulgaris containing a single Cys, near the active site His, and inhibited by p-mercuribenzoate. The N-terminal extension of the polypeptide chain relative to subtilisin contributes to Ca2+-binding and the high thermostability. The amino acid composition and properties of the thermostable enzyme from Streptomyces rectus var. proteolyticus (formerly included in EC 3.4.21.14) are closely similar [1,2].
History
EC 3.4.21.66 created 1992
Orthology
K08651  
thermitase
Genes
PPHE: 
TIG: 
AZA: 
AZI: 
BBAT: 
BBW: 
BBAC: 
BEX: 
MYM: 
MALG: 
BAN: 
BAR: 
BAT: 
BAH: 
BAI: 
BAX: 
BANT: 
BANR: 
BANS: 
BANH: 
BANV: 
BAL: 
BCE: 
BCA: 
BCZ: 
BCR: 
BCB: 
BCU: 
BCG: 
BCQ: 
BCX: 
BNC: 
BCF: 
BCER: 
BCEF: 
BCY: 
BTK: 
BTL: 
BTB: 
BTT: 
BTHR: 
BTHI: 
BTC: 
BTF: 
BTM: 
BTG: 
BTI: 
BTN: 
BTHT: 
BTHU: 
BTW: 
BTY: 
BMYC: 
BMH: 
BCO: 
BBY: 
OIH: 
FPN: 
BLR: 
CML: 
CCB: 
APN: 
PSUL: 
RRD: 
DPD: 
FGI: 
TPED: 
TPE_1950(prtP)
GBA: 
HHY: 
SGN: 
FLI: 
IAL: 
MIB: 
 » show all
Taxonomy
Reference
1  [PMID:4711613]
  Authors
Mizusawa K, Yoshida F.
  Title
Thermophilic Streptomyces alkaline proteinase. II. The role of a sulfhydryl group and the conformational stability.
  Journal
J. Biol. Chem. 248 (1973) 4417-23.
Reference
2  [PMID:4373436]
  Authors
Borgia P, Campbell LL.
  Title
Properties of two homologous alkaline proteases from Streptomyces rectus.
  Journal
J. Bacteriol. 120 (1974) 1109-15.
Reference
3  [PMID:7051706]
  Authors
Kleine R.
  Title
Properties of thermitase, a thermostable serine protease from Thermoactinomyces vulgaris.
  Journal
Acta. Biol. Med. Ger. 41 (1982) 89-102.
Reference
4
  Authors
Meloun, B., Baudy, M., Kostka, V., Hausdorf, G., Frommel, C. and Hohne, W.E.
  Title
Complete primary structure of thermitase from Thermoactinomyces vulgaris and its structural features related to the subtilisin-type proteinases.
  Journal
FEBS Lett. 183 (1985) 195-200.
Reference
5  [PMID:2196375]
  Authors
Teplyakov AV, Kuranova IP, Harutyunyan EH, Vainshtein BK, Frommel C, Hohne WE, Wilson KS.
  Title
Crystal structure of thermitase at 1.4 A resolution.
  Journal
J. Mol. Biol. 214 (1990) 261-79.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
69772-87-8

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