KEGG   ENZYME: 3.4.21.72Help
Entry
EC 3.4.21.72                Enzyme                                 

Name
IgA-specific serine endopeptidase;
IgA protease;
IgA proteinase;
IgA-specific proteinase;
immunoglobulin A protease;
immunoglobulin A proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of immunoglobulin A molecules at certain Pro! bonds in the hinge region. No small molecule substrates are known
Comment
Species variants differing slightly in specificity are secreted by Gram-negative bacteria Neisseria gonorrhoeae and Haemophilus influenzae. Type example of peptidase family S6. Some other bacterial endopeptidases with similar specificity are of metallo- type (see EC 3.4.24.13, IgA-specific metalloendopeptidase)
History
EC 3.4.21.72 created 1992
Orthology
K01347  IgA-specific serine endopeptidase
Genes
HIN: HI0990(iga1)
HIT: NTHI0354(hap) NTHI1164(iga1)
HIP: CGSHiEE_07015(recF)
HIF: HIBPF_12570
HIL: HICON_04100
HIU: HIB_03070 HIB_11300(iga)
HIE: R2846_0355(hap1) R2846_1321(iga)
HIZ: R2866_0337(hap1) R2866_1393(iga)
HIK: HifGL_000025(hap) HifGL_000617(iga)
HIA: H733_0142 H733_1448
MHX: MHH_c09480(hap1) MHH_c11330(iga1) MHH_c11860(iga2) MHH_c14860
BTO: WQG_4340
BTRE: F542_17690
BTRH: F543_19470
BTRA: F544_4640
NME: NMB0700(iga) NMB1985(hap) NMB1998
NMC: NMC0651(iga) NMC1959(iga2)
NMN: NMCC_0223(app) NMCC_0659(iga)
NMT: NMV_1699(iga) NMV_2184(app)
NMI: NMO_0169 NMO_0193(iga2) NMO_0592(iga1)
NMW: NMAA_0168(app) NMAA_0537(iga)
NLA: NLA_19200(iga2)
LLM: llmg_0877
 » show all
Taxonomy
Reference
1  [PMID:6416146]
  Authors
Plaut AG.
  Title
The IgA1 proteases of pathogenic bacteria.
  Journal
Annu. Rev. Microbiol. 37 (1983) 603-22.
Reference
2  [PMID:2105953]
  Authors
Bachovchin WW, Plaut AG, Flentke GR, Lynch M, Kettner CA.
  Title
Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids.
  Journal
J. Biol. Chem. 265 (1990) 3738-43.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.72
IUBMB Enzyme Nomenclature: 3.4.21.72
ExPASy - ENZYME nomenclature database: 3.4.21.72
BRENDA, the Enzyme Database: 3.4.21.72
CAS: 55127-02-1

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