KEGG   ENZYME: 3.4.21.78Help
Entry
EC 3.4.21.78                Enzyme                                 

Name
granzyme A;
CTLA3;
HuTPS;
T-cell associated protease 1;
cytotoxic T lymphocyte serine protease;
TSP-1;
T-cell derived serine proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg!, -Lys! >> -Phe! in small molecule substrates
Comment
From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family). The human enzyme does not cleave Phe!-
History
EC 3.4.21.78 created 1993
Orthology
K01352  
granzyme A
Genes
HSA: 
3001(GZMA)
PTR: 
461873(GZMA)
PPS: 
100984053(GZMA)
GGO: 
101143719(GZMA)
PON: 
100445064(GZMA)
NLE: 
100604986(GZMA)
MCC: 
705712(GZMA)
MCF: 
102143423(GZMA)
CSAB: 
103221481(GZMA)
RRO: 
104680493(GZMA)
CJC: 
100408119(GZMA)
SBQ: 
101036387(GZMA)
MMU: 
14938(Gzma)
RNO: 
266708(Gzma)
CGE: 
NGI: 
HGL: 
101726631(Gzma)
OCU: 
TUP: 
102467739(GZMA)
CFA: 
487207(GZMA)
AML: 
100476014(GZMA)
UMR: 
103663680(GZMA)
FCA: 
100113480(GZMA)
PTG: 
102949286(GZMA)
BTA: 
407178(gzmA) 539093(GZMA)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
100233183(GZMA) 100526762(GZMA)
CFR: 
BACU: 
LVE: 
ECB: 
100062497(GZMA)
MYB: 
102250453(GZMA)
MYD: 
102761771(GZMA)
PALE: 
102898995(GZMA)
LAV: 
100676692(GZMA)
MDO: 
100031794(GZMA)
SHR: 
100932934(GZMA)
GGA: 
395108(GZMA)
MGP: 
CJO: 
TGU: 
100225754(GZMA)
GFR: 
FAB: 
101821368(GZMA)
PHI: 
102106832(GZMA)
CCW: 
FPG: 
FCH: 
CLV: 
102093295(GZMA)
AAM: 
ASN: 
102381782(GZMA)
AMJ: 
102558867(GZMA)
PSS: 
102462891(GZMA)
CMY: 
102931660(GZMA)
ACS: 
PBI: 
GJA: 
XLA: 
379554(gzma)
XTR: 
100135014(gzma) 100497188(gzmAK)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
100196008(graa) 106570903(GRAA)
LCM: 
CMK: 
 » show all
Taxonomy
Reference
1  [PMID:3545816]
  Authors
Simon MM, Hoschutzky H, Fruth U, Simon HG, Kramer MD.
  Title
Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes.
  Journal
EMBO. J. 5 (1986) 3267-74.
Reference
2  [PMID:3257574]
  Authors
Gershenfeld HK, Hershberger RJ, Shows TB, Weissman IL.
  Title
Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 1184-8.
  Sequence
[hsa:3001]
Reference
3  [PMID:1998680]
  Authors
Odake S, Kam CM, Narasimhan L, Poe M, Blake JT, Krahenbuhl O, Tschopp J, Powers JC.
  Title
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins.
  Journal
Biochemistry. 30 (1991) 2217-27.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
143180-73-8

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