KEGG   ENZYME: 3.4.21.82Help
Entry
EC 3.4.21.82                Enzyme                                 

Name
glutamyl endopeptidase II;
GluSGP
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: -Glu! >> -Asp! . Preference for Pro or Leu at P2 and Phe at P3. Cleavage of -Glu!Asp- and -Glu!Pro- bonds is slow
Comment
From Streptomyces griseus. A peptidase of family S1 (trypsin family). Inhibited by [Leu18->Glu]-modified turkey ovomucoid third domain
History
EC 3.4.21.82 created 1993
Orthology
K18548  
glutamyl endopeptidase II
Genes
SGR: 
SGR_1986(sprE)
SFI: 
Taxonomy
Reference
1  [PMID:3149277]
  Authors
Yoshida N, Tsuruyama S, Nagata K, Hirayama K, Noda K, Makisumi S.
  Title
Purification and characterization of an acidic amino acid specific endopeptidase of Streptomyces griseus obtained from a commercial preparation (Pronase).
  Journal
J. Biochem. (Tokyo). 104 (1988) 451-6.
Reference
2  [PMID:1674942]
  Authors
Komiyama T, Bigler TL, Yoshida N, Noda K, Laskowski M Jr.
  Title
Replacement of P1 Leu18 by Glu18 in the reactive site of turkey ovomucoid third domain converts it into a strong inhibitor of Glu-specific Streptomyces griseus proteinase (GluSGP).
  Journal
J. Biol. Chem. 266 (1991) 10727-30.
Reference
3  [PMID:1794975]
  Authors
Nagata K, Yoshida N, Ogata F, Araki M, Noda K.
  Title
Subsite mapping of an acidic amino acid-specific endopeptidase from Streptomyces griseus, GluSGP, and protease V8.
  Journal
J. Biochem. (Tokyo). 110 (1991) 859-62.
Reference
4  [PMID:1959600]
  Authors
Svendsen I, Jensen MR, Breddam K.
  Title
The primary structure of the glutamic acid-specific protease of Streptomyces griseus.
  Journal
FEBS. Lett. 292 (1991) 165-7.
  Sequence
[sgr:SGR_1986]
Reference
5  [PMID:1587264]
  Authors
Breddam K, Meldal M.
  Title
Substrate preferences of glutamic-acid-specific endopeptidases assessed by synthetic peptide substrates based on intramolecular fluorescence quenching.
  Journal
Eur. J. Biochem. 206 (1992) 103-7.
  Sequence
[sgr:SGR_1986]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
137010-42-5

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