KEGG   ENZYME: 3.4.21.86Help
Entry
EC 3.4.21.86                Enzyme                                 

Name
limulus clotting enzyme;
clotting enzyme
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of -Arg18! and -Arg47! bonds in coagulogen to form coagulin and fragments
Comment
From the hemocyte granules of horseshoe crabs Limulus and Tachypleus. Proclotting enzyme is activated by limulus clotting factor . In peptidase family S1 (trypsin family)
History
EC 3.4.21.86 created 1993
Orthology
K20753  
limulus clotting enzyme
Genes
AME: 
550671(SP3)
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
100118620(SP44)
TCA: 
103313165(P140) 659360(P55)
BMOR: 
692435(CLIP4)
PXY: 
API: 
PHU: 
DPX: 
ISC: 
 » show all
Taxonomy
Reference
1  [PMID:2266134]
  Authors
Muta T, Hashimoto R, Miyata T, Nishimura H, Toh Y, Iwanaga S.
  Title
Proclotting enzyme from horseshoe crab hemocytes. cDNA cloning, disulfide locations, and subcellular localization.
  Journal
J. Biol. Chem. 265 (1990) 22426-33.
  Sequence
Reference
2  [PMID:2016264]
  Authors
Tokunaga F, Nakajima H, Iwanaga S.
  Title
Further studies on lipopolysaccharide-sensitive serine protease zymogen (factor C): its isolation from Limulus polyphemus hemocytes and identification as an intracellular zymogen activated by alpha-chymotrypsin, not by trypsin.
  Journal
J. Biochem. (Tokyo). 109 (1991) 150-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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