KEGG   ENZYME: 3.4.21.98Help
Entry
EC 3.4.21.98                Enzyme                                 

Name
hepacivirin;
Cpro-2;
hepatitis C virus NS3 serine proteinase;
NS3-4A serine proteinase complex
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'
Comment
Encoded by the genome of the viruses of the hepatitis C group, and contributes to the maturation of the precursor polyproteins. The enzyme is greatly activated by binding of the 54-residue NS4A 'cofactor' protein also derived from the viral polyprotein. Type example of peptidase family S29. The crystallographic structure shows a chymotrypsin-like fold.
History
EC 3.4.21.98 created 2000
Reference
1  [PMID:8861917]
  Authors
Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET, Harbeson SL, Rice CM, Murcko MA, Caron PR, Thomson JA.
  Title
Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide.
  Journal
Cell. 87 (1996) 343-55.
  Organism
Hepatitis C virus
  Sequence
[up:P27958]
Reference
2
  Authors
Rice, C.M.
  Title
Hepatitis C virus polyprotein peptidase.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 272-277.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
149885-80-3

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