| Entry |
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| Name |
cathepsin L;
Aldrichina grahami cysteine proteinase
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
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| Reaction(IUBMB) |
Similar to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity
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| Comment |
A lysosomal enzyme in peptidase family C1 (papain family) that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN2 or the epoxide inhibitor E-64
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| Orthology |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | NVI: | | TCA: | | API: | | PHU: | | CEL: | | CBR: | | BMY: | | NVE: | | HMG: | | TAD: | | AQU: | | MTR: | | OLU: | | OTA: | | MBR: | | DDI: | | EDI: | | TET: | | TVA: | | PTI: | | TPS: | |
» show all
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| Reference |
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| Authors |
Barrett AJ, Kirschke H. |
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| Title |
Cathepsin B, Cathepsin H, and cathepsin L. |
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| Journal |
Methods. Enzymol. 80 Pt C (1981) 535-61. |
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| Reference |
2 |
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| Authors |
Barrett, A.J., Buttle, D.J. and Mason, R.W. |
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| Title |
Lysosomal cysteine proteinases. |
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| Journal |
ISI Atlas of Science. Biochemistry 1 (1988) 256-260. |
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| Reference |
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| Authors |
Joseph LJ, Chang LC, Stamenkovich D, Sukhatme VP. |
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| Title |
Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts. |
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| Journal |
J. Clin. Invest. 81 (1988) 1621-9. |
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| Organism |
Homo sapiens [GN: hsa], Mus musculus [GN: mmu] |
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| Reference |
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| Authors |
Kirschke H, Wikstrom P, Shaw E. |
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| Title |
Active center differences between cathepsins L and B: the S1 binding region. |
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| Journal |
FEBS. Lett. 228 (1988) 128-30. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 60616-82-2 |
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