KEGG   ENZYME: 3.4.22.34Help
Entry
EC 3.4.22.34                Enzyme                                 

Name
legumain;
asparaginyl endopeptidase;
citvac;
proteinase B (ambiguous);
hemoglobinase (ambiguous);
PRSC1 gene product (Homo sapiens);
vicilin peptidohydrolase;
bean endopeptidase;
vicilin peptidohydrolase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins and small molecule substrates at -Asn!Xaa- bonds
Comment
Best known from legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes. Not inhibited by compound E-64. Type example of peptidase family C13
History
EC 3.4.22.34 created 1992, modified 2000
Orthology
K01369  legumain
Genes
HSA: 5641(LGMN)
PTR: 453118(LGMN)
PPS: 100979480(LGMN) 100982269
GGO: 101136467(LGMN)
PON: 100173793(LGMN)
NLE: 100589580(LGMN)
MCC: 703734(LGMN)
MCF: 101867471(LGMN)
CSAB: 103229573(LGMN)
RRO: 104679044(LGMN)
RBB: 108519101(LGMN)
CJC: 100415145(LGMN)
SBQ: 101041065(LGMN)
MMU: 19141(Lgmn)
RNO: 63865(Lgmn)
CGE: 100752348(Lgmn)
NGI: 103724596(Lgmn)
HGL: 101698288(Lgmn)
CCAN: 109696677(Lgmn)
OCU: 100346565(LGMN)
TUP: 102474276(LGMN)
CFA: 480232(LGMN)
AML: 100464092(LGMN)
UMR: 103670076(LGMN)
ORO: 101384948(LGMN)
FCA: 101098470(LGMN)
PTG: 102969813(LGMN)
AJU: 106980834(LGMN)
BTA: 281281(LGMN)
BOM: 102279974(LGMN)
PHD: 102332201(LGMN)
CHX: 102191183(LGMN)
OAS: 678680(LGMN)
SSC: 100154477(LGMN)
CFR: 102509831(LGMN)
CDK: 105095852(LGMN)
BACU: 103013176(LGMN)
LVE: 103083212(LGMN)
OOR: 101269340(LGMN)
ECB: 100053265(LGMN)
EPZ: 103556526(LGMN)
EAI: 106825364(LGMN)
MYB: 102254818(LGMN)
MYD: 102768828(LGMN)
HAI: 109376792(LGMN)
RSS: 109454588(LGMN)
PALE: 102889046(LGMN)
LAV: 100667671(LGMN)
TMU: 101343432
MDO: 100016534(LGMN)
SHR: 100923637(LGMN)
OAA: 100079679(LGMN)
GGA: 423418(LGMN)
MGP: 100540998(LGMN)
CJO: 107315211(LGMN)
APLA: 101801019(LGMN)
ACYG: 106036483(LGMN)
TGU: 100220965(LGMN)
GFR: 102039394(LGMN)
FAB: 101806290(LGMN)
PHI: 102106609(LGMN)
PMAJ: 107206007(LGMN)
CCW: 104686131(LGMN)
FPG: 101914771(LGMN)
FCH: 102057063(LGMN)
CLV: 102094176(LGMN)
EGZ: 104135339(LGMN)
AAM: 106482935(LGMN)
ASN: 102373928(LGMN)
AMJ: 102570177(LGMN)
PSS: 102451298(LGMN)
CMY: 102947732(LGMN)
CPIC: 101947250(LGMN)
ACS: 100567178(lgmn)
PVT: 110083625(LGMN)
PBI: 103052653(LGMN)
GJA: 107123821(LGMN)
XLA: 108699819(lgmn.S) 379601(lgmn.L)
XTR: 448252(lgmn)
NPR: 108788679(LGMN)
TRU: 101076709(lgmn)
LCO: 104929778(lgmn)
MZE: 101483614(lgmn)
OLA: 101163371(lgmn)
XMA: 102237395(lgmn)
PRET: 103458294(lgmn)
NFU: 107391750(lgmn)
CSEM: 103381136(lgmn)
LCF: 108886685(lgmn)
HCQ: 109517472(lgmn)
BPEC: 110171101(lgmn)
SASA: 100306856(lgmn) 106589466
ELS: 105015924(lgmn)
LCM: 102350037(LGMN)
CMK: 103185394(lgmn) 103188950
CIN: 100182585
SPU: 100889415
SKO: 100376285
ZNE: 110828600
FCD: 110844609
CEL: CELE_T28H10.3(T28H10.3)
CBR: CBG23516
BMY: Bm1_50230
CRG: 105319353
MYI: 110450417
OBI: 106883408
SHX: MS3_09207
EPA: 110252650
ADF: 107327341
HMG: 100207098
ATH: AT1G62710(BETA-VPE) AT2G25940(ALPHA-VPE) AT3G20210(DELTA-VPE) AT4G32940(GAMMA-VPE)
LJA: Lj0g3v0195629.1(Lj0g3v0195629.1) Lj0g3v0270939.1(Lj0g3v0270939.1) Lj0g3v0270939.2(Lj0g3v0270939.2) Lj1g3v1785750.1(Lj1g3v1785750.1) Lj2g3v1877640.1(Lj2g3v1877640.1) Lj2g3v1877640.2(Lj2g3v1877640.2) Lj5g3v0369970.1(Lj5g3v0369970.1)
RCU: 8272115(VPE) 8275625
DOSA: Os01t0559600-01(Os01g0559600) Os02t0644000-01(Os02g0644000) Os04t0537900-01(Os04g0537900) Os05t0593900-01(Os05g0593900) Os06t0105100-00(Os06g0105100)
ATS: 109740567(LOC109740567) 109746962(LOC109746962) 109752674(LOC109752674) 109752680(LOC109752680) 109761353(LOC109761353) 109765815(LOC109765815) 109765816(LOC109765816) 109773848(LOC109773848) 109775604(LOC109775604)
ZMA: 100192667 100286140(pco079297) 542001(see2a) 542077(vpe1) 542609(pco131778b)
CRE: CHLREDRAFT_196085(VPE1)
APRO: F751_1333
SMIN: v1.2.032754.t1(symbB.v1.2.032754.t1)
SPAR: SPRG_06015
EHX: EMIHUDRAFT_455379(AEP1)
 » show all
Taxonomy
Reference
1
  Authors
Hara-Nishimura, I.
  Title
Asparaginyl endopeptidase.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 746-749.
Reference
2
  Authors
Dalton, J.P. and Brindley, P.J.
  Title
Schistosome legumain.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 749-754.
Reference
3  [PMID:9891971]
  Authors
Chen JM, Rawlings ND, Stevens RA, Barrett AJ.
  Title
Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases.
  Journal
FEBS. Lett. 441 (1998) 361-5.
  Sequence
[mmu:19141]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.34
IUBMB Enzyme Nomenclature: 3.4.22.34
ExPASy - ENZYME nomenclature database: 3.4.22.34
BRENDA, the Enzyme Database: 3.4.22.34
CAS: 149371-18-6

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