KEGG   ENZYME: 3.4.22.51Help
Entry
EC 3.4.22.51                Enzyme                                 

Name
cruzipain;
congopain;
cruzain;
evansain;
trypanopain
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Broad endopeptidase specificity similar to that of cathepsin L
Comment
In peptidase family C1. Is located in the digestive vacuoles of the parasitic trypanosome and contributes to the nutrition of the organism by digestion of host proteins.
History
EC 3.4.22.51 created 2003
Orthology
K08571  
cruzipain
Reference
1  [PMID:11472258]
  Authors
Jose Cazzulo J, Stoka V, Turk V.
  Title
The major cysteine proteinase of Trypanosoma cruzi: a valid target for chemotherapy of Chagas disease.
  Journal
Curr. Pharm. Des. 7 (2001) 1143-56.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
141588-22-9

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