KEGG   ENZYME: 3.4.22.62Help
Entry
EC 3.4.22.62                Enzyme                                 

Name
caspase-9;
CASP-9;
ICE-like apoptotic protease 6;
ICE-LAP6;
apoptotic protease Mch-6;
apoptotic protease-activating factor 3;
APAF-3
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp!Xaa
Comment
Caspase-9 is an initiator caspase, as are caspase -2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-10 (EC 3.4.22.63) [1]. Caspase-9 contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [1]. An alternatively spliced version of caspase-9 also exists, caspase-9S, that inhibits apoptosis, similar to the situation found with caspase-2 [1]. Phosphorylation of caspase-9 from some species by Akt, a serine-threonine protein kinase, inhibits caspase activity in vitro and caspase activation in vivo [1]. The activity of caspase-9 is increased dramatically upon association with the apoptosome but the enzyme can be activated without proteolytic cleavage [2,3]. Procaspase-3 is the enzyme's physiological substrate [2]. Belongs in peptidase family C14.
History
EC 3.4.22.62 created 2007
Orthology
K04399  caspase 9
Genes
HSA: 842(CASP9)
PTR: 456457(CASP9)
PPS: 100992567(CASP9)
GGO: 101130414(CASP9)
PON: 100460459(CASP9)
NLE: 100597173(CASP9)
MCC: 694544(CASP9)
MCF: 102126830(CASP9)
CSAB: 103225550(CASP9)
RRO: 104677696(CASP9)
RBB: 108524269(CASP9)
CJC: 100409028(CASP9)
SBQ: 101051525(CASP9)
MMU: 12371(Casp9)
RNO: 58918(Casp9)
NGI: 103725336(Casp9)
HGL: 101702898(Casp9)
CCAN: 109692548(Casp9)
OCU: 100101592(CASP9)
TUP: 102470940(CASP9)
CFA: 487432(CASP9)
AML: 100483760(CASP9)
UMR: 103666628(CASP9)
ORO: 101362812(CASP9)
FCA: 768260(CASP9)
PTG: 102967404(CASP9)
AJU: 106975594(CASP9)
BTA: 100140945(CASP9)
BOM: 102268660(CASP9)
BIU: 109570433(CASP9)
PHD: 102336217(CASP9)
CHX: 102174681(CASP9)
OAS: 101110953(CASP9)
SSC: 100518913(CASP9)
CFR: 102519816(CASP9)
CDK: 105107056(CASP9)
BACU: 103010071(CASP9)
LVE: 103086745(CASP9)
OOR: 101271677(CASP9)
ECB: 100054331(CASP9)
EPZ: 103565016(CASP9)
EAI: 106828005(CASP9)
MYB: 102254877(CASP9)
MYD: 102759481(CASP9)
HAI: 109381302(CASP9)
RSS: 109459000(CASP9)
PALE: 102878565(CASP9)
LAV: 100656597(CASP9)
TMU: 101355103
MDO: 100027338(CASP9)
SHR: 100931481(CASP9)
OAA: 100092345(CASP9)
GGA: 426970(CASP9)
MGP: 100550410(CASP9)
CJO: 107323418(CASP9)
APLA: 101795386(CASP9)
ACYG: 106040238(CASP9)
TGU: 100227981(CASP9)
GFR: 102039030(CASP9)
FAB: 101808292(CASP9)
PHI: 102108950(CASP9)
PMAJ: 107213687(CASP9)
CCW: 104697549(CASP9)
FPG: 101914844(CASP9)
FCH: 102054465(CASP9)
CLV: 102093506(CASP9)
EGZ: 104133155(CASP9)
AAM: 106493414(CASP9)
ASN: 102384999(CASP9)
AMJ: 102573968(CASP9)
PSS: 102443524(CASP9)
CMY: 102939753(CASP9)
CPIC: 101944555(CASP9)
ACS: 100560103(casp9)
PVT: 110072690(CASP9)
PBI: 103063403(CASP9)
GJA: 107124463(CASP9)
XLA: 373560(casp9.S)
XTR: 100144708(casp9)
NPR: 108797190(CASP9)
DRE: 492763(casp9)
IPU: 108276164(casp9)
AMEX: 103034324
TRU: 101075121(casp9)
LCO: 104939007(casp9)
NCC: 104954971
MZE: 101487562(casp9)
OLA: 101157857(casp9)
XMA: 102226741(casp9)
PRET: 103467149(casp9)
CSEM: 103385017(casp9)
LCF: 108882570(casp9)
HCQ: 109511699(casp9)
BPEC: 110167143(casp9)
SASA: 106567147 106572551(casp9)
ELS: 105028691(casp9)
SFM: 108939364(casp9)
LCM: 102362720(CASP9)
CMK: 103187647(casp9)
SKO: 100376094
CRG: 105325340
EPA: 110241763
ADF: 107343798
HMG: 101235218
AQU: 100633941
 » show all
Taxonomy
Reference
1  [PMID:11104820]
  Authors
Chang HY, Yang X.
  Title
Proteases for cell suicide: functions and regulation of caspases.
  Journal
Microbiol. Mol. Biol. Rev. 64 (2000) 821-46.
Reference
2  [PMID:16630893]
  Authors
Yin Q, Park HH, Chung JY, Lin SC, Lo YC, da Graca LS, Jiang X, Wu H.
  Title
Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine.
  Journal
Mol. Cell. 22 (2006) 259-68.
Reference
3  [PMID:12620239]
  Authors
Boatright KM, Renatus M, Scott FL, Sperandio S, Shin H, Pedersen IM, Ricci JE, Edris WA, Sutherlin DP, Green DR, Salvesen GS.
  Title
A unified model for apical caspase activation.
  Journal
Mol. Cell. 11 (2003) 529-41.
Reference
4
  Authors
Salvesen, G.S. and Boatright, K.M.
  Title
Caspase-9.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, 2nd ed., Elsevier, London, 2004, p. 1296-1298.
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.62
IUBMB Enzyme Nomenclature: 3.4.22.62
ExPASy - ENZYME nomenclature database: 3.4.22.62
BRENDA, the Enzyme Database: 3.4.22.62
CAS: 180189-96-2

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