KEGG   ENZYME: 3.4.22.70Help
Entry
EC 3.4.22.70                Enzyme                                 

Name
sortase A;
SrtA;
SrtA protein;
SrtA sortase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
The enzyme catalyses a cell wall sorting reaction in which a surface protein with a sorting signal containing a LPXTG motif is cleaved between the Thr and Gly residue. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan.
Comment
In peptidase family C60.
History
EC 3.4.22.70 created 2009
Orthology
K07284  sortase A
K08600  sortase B
Genes
SON: SO_2196(srtA)
SFR: Sfri_1626
SAZ: Sama_2002
SBL: Sbal_1844
SBM: Shew185_1830
SBN: Sbal195_1878
SBP: Sbal223_2447
SBT: Sbal678_1917
SBS: Sbal117_1962
SBB: Sbal175_2509
SLO: Shew_1794
SSE: Ssed_2491
SPL: Spea_2515
SHL: Shal_1737
SWD: Swoo_2125
SWP: swp_3091
SVO: SVI_1841
CPS: CPS_3380
PHA: PSHAa0631
PAT: Patl_3923
PSEO: OM33_05920
PSPO: PSPO_a0600(srtA)
PTU: PTUN_a3420(srtA)
MAQ: Maqu_3683
MHC: MARHY3592
MAD: HP15_3445
AMAC: MASE_13650
GNI: GNIT_0711(srtA)
GPS: C427_0550 C427_0551(srtA)
SDE: Sde_0123
SAGA: M5M_19010
TIG: THII_2405
HCH: HCH_00090
ADI: B5T_00100
AXE: P40_00505
KKO: Kkor_2416
KGE: TQ33_0146
TBN: TBH_C1252
DSF: UWK_00696
PLA: Plav_2294
RLE: RL3445
RLG: Rleg_2999
OAN: Oant_4847
OAH: DR92_3728
BJA: bll0976
BRA: BRADO6888
BBT: BBta_0663
BRS: S23_68310
AOL: S58_05880
BRAD: BF49_7211
MEX: Mext_1399
MDI: METDI2057
MCH: Mchl_1674
MET: M446_5133
MPO: Mpop_1394
MOR: MOC_5872
META: Y590_06480
RBM: TEF_17890
MAGQ: MGMAQ_3206
BSU: BSU09200(yhcS) BSU36340(ywpE)
BSH: BSU6051_09200(yhcS) BSU6051_36340(ywpE)
BSUT: BSUB_01015(yhcS) BSUB_03868(ywpE)
BSUL: BSUA_01015(yhcS) BSUA_03868(ywpE)
BSO: BSNT_07352(yhcS) BSNT_10283(ywpE)
BSQ: B657_09200(srtA) B657_36340(ywpE)
BSX: C663_0943(yhcS)
BLI: BL00120(ywpE) BL03172(yhcS)
BLD: BLi00602 BLi00983(yhcS)
BAY: RBAM_009460(yhcS)
BAQ: BACAU_0749(srtA) BACAU_0906(yhcS)
BYA: BANAU_0694(srtA) BANAU_0851(yhcS)
BAML: BAM5036_0848(srtA)
BAMA: RBAU_0909(srtA)
BAMN: BASU_0885(srtA)
BAMB: BAPNAU_0705(srtA) BAPNAU_2856(yhcS)
BAMY: V529_07160(srtA) V529_08810
BAO: BAMF_0725(ywpE) BAMF_1016(yhcS)
BAZ: BAMTA208_03430(ywpE) BAMTA208_04290(yhcS)
BQL: LL3_00779(ywpE) LL3_01001(yhcS)
BQY: MUS_0770(ywpE) MUS_0957(yhcS)
BAMC: U471_09280
BAN: BA_0688 BA_4783(srtB) BA_5069
BWW: bwei_0069 bwei_0353(srtB) bwei_3288(srtA3) bwei_4908(srtA2) bwei_5790(srtA)
BMQ: BMQ_3150
BMD: BMD_3175
BMEG: BG04_81
BACP: SB24_05150
BACO: OXB_1111
BEO: BEH_07425
OIH: OB0332
GKA: GK2003
AFL: Aflv_2645
AAMY: GFC30_434
AXL: AXY_19090
LSP: Bsph_0953(srtA) Bsph_1270
SAU: SA0982(srtB) SA2316(srtA)
SAV: SAV1135 SAV2528(srtA)
SAW: SAHV_1126 SAHV_2512(srtA)
SAM: MW1017(srtB) MW2448(srtA)
SAR: SAR1108(srtB) SAR2608(srtA)
SAC: SACOL1145(srtB) SACOL2539(srtA)
SAX: USA300HOU_2517(srtA)
SAA: SAUSA300_1034(srtB) SAUSA300_2467(srtA)
SAE: NWMN_1046(srtB) NWMN_2426(srtA)
SAD: SAAV_1101(srtB) SAAV_2593(srtA)
SUE: SAOV_1131(srtB) SAOV_2571c
SUJ: SAA6159_00989(srtB) SAA6159_02424(srtA)
SUK: SAA6008_01089(srtB) SAA6008_02566(srtA)
SUC: ECTR2_2380 ECTR2_989(srtB)
SUZ: MS7_1091(srtB) MS7_2534(srtA)
SUW: SATW20_11290(srtB) SATW20_26490(srtA)
SUG: SAPIG1131(srtB) SAPIG2578
SAUE: RSAU_001019(srtB) RSAU_002369(srtA)
SAUS: SA40_1005(srtB) SA40_2281(srtA)
SAUU: SA957_1020(srtB) SA957_2365(srtA)
SAUG: SA268_1023(srtB) SA268_2442(srtA)
SAUZ: SAZ172_1134(srtB) SAZ172_2626(srtA)
SAB: SAB0999(srtB) SAB2402c(srtA)
SUY: SA2981_1091(srtB) SA2981_2464(srtA)
SAUB: C248_1161(srtB) C248_2585(srtA)
SAUC: CA347_1049(srtB) CA347_2602
SAUR: SABB_01155(srtA) SABB_02601
SAUF: X998_1132(srtB) X998_2511
SER: SERP2089(srtA)
SEPP: SEB_02082
SEPS: DP17_1025
SHA: SH0543(srtA)
SHH: ShL2_00438(srtA)
SSP: SSP0371
SCA: SCA_2003(srtA)
SLN: SLUG_00990(srtB) SLUG_04700(srtA)
SDT: SPSE_0356(srtA)
SPAS: STP1_1019
SXO: SXYL_00402(srtA)
SHU: SHYC_02315(srtA)
SSCH: LH95_02050
SSCZ: RN70_02360
SAGQ: EP23_07820
LMQ: LMM7_0965(srtA) LMM7_2283(srtB)
LML: lmo4a_0944(srtA) lmo4a_2242(srtB)
LMOL: LMOL312_0930(srtA) LMOL312_2200(srtB)
LWE: lwe0907(srtA) lwe2198
LSG: lse_0827(srtA) lse_2161
LIV: LIV_2168
ESI: Exig_0466
EAN: Eab7_0442(srtA)
PPM: PPSC2_02235(srtA) PPSC2_25225(srtB)
PPO: PPM_0402(srtA) PPM_5011(srtB)
PPOL: X809_01815
PPQ: PPSQR21_004070(srtA)
PSAB: PSAB_02980
PSWU: SY83_05140
AAC: Aaci_0149
AAD: TC41_0190(srtA)
BTS: Btus_1032
JEO: JMA_37570
KUR: ASO14_346
LLA: L125196(ylcC) L169709(yhhA)
LLK: LLKF_0779(srtC) LLKF_1140(srtA) LLKF_1396(srtB)
LLT: CVCAS_0722(srtC) CVCAS_1086(srtA)
LLS: lilo_0690(yhhA) lilo_1016(ylcC)
LLX: NCDO2118_0775(srtC) NCDO2118_1116(srtA) NCDO2118_1359(srtB)
LLM: llmg_1449(srtA) llmg_1801(srtC)
LLI: uc509_1118(srtA)
LLJ: LG36_0744(srtC) LG36_1265(srtA)
LGR: LCGT_1291
LGV: LCGL_1312
LPK: LACPI_0534(srtA1) LACPI_0535(srtC) LACPI_1344(srtA2)
SPF: SpyM50107(srtB) SpyM50915(srtA)
STX: MGAS1882_0143(srtC) MGAS1882_0147(srtB) MGAS1882_0870(srtA)
SPYA: A20_0157(srtB) A20_0163(srtC) A20_0913
SPD: SPD_1076(srtA)
SPR: spr1098(srtA)
SPW: SPCG_1083
SPX: SPG_1110
SNE: SPN23F11150(srtA)
SPV: SPH_1333
SJJ: SPJ_1133
SPP: SPP_1256
SNP: SPAP_1191(srtG2) SPAP_1192(srtG1) SPAP_1244
SNV: SPNINV200_10160(srtA)
SNX: SPNOXC10890(srtA)
SNU: SPNA45_00970(srtA)
SPNE: SPN034156_01770(srtA)
SPNU: SPN034183_10890(srtA)
SPNM: SPN994038_10780(srtA)
SPNO: SPN994039_10790(srtA)
SAG: SAG0647 SAG0648 SAG0961(srtA)
SGC: A964_0939(srtA) A964_1320
SAGP: V193_04450
SAGC: DN94_04450
SAGN: W903_1028
SMU: SMU_1113(srtA)
SMC: SmuNN2025_0928(srtA)
SMJ: SMULJ23_0926(srtA)
SMUA: SMUFR_0971(srtA)
STC: str1277
STL: stu1277
STE: STER_1255
STN: STND_1228
STW: Y1U_C1195
STHE: T303_07335
SSA: SSA_0022(srtB) SSA_1219(srtA) SSA_1631(srtC)
SSB: SSUBM407_0856(srtA)
SSI: SSU0428 SSU0453(srtE) SSU0925(srtA)
SSS: SSUSC84_0968(srtA)
SSQ: SSUD9_0495(srtC1) SSUD9_0525 SSUD9_1248(srtA)
SSUT: TL13_0526(strA) TL13_0872(srtA)
SGO: SGO_1230(srtA) SGO_2104(srtB)
SEZ: Sez_0813(srtC.1) Sez_1020(srtA) Sez_1820(srtC.2) Sez_1826(srtC.3) Sez_1827(srtC.4)
SEZO: SeseC_01090(srtA) SeseC_01347(srtA) SeseC_02470(srtA) SeseC_02471(srtC)
SUB: SUB0881(srtA)
SDA: GGS_0156(srtC.4) GGS_0157(srtC.3) GGS_0159(srtC.4) GGS_0160(srtC.3) GGS_0889(srtA) GGS_1595 GGS_1598(eftLSL-B)
SGT: SGGB_0178(srtA1) SGGB_1117(srtA2) SGGB_1566(srtC1) SGGB_1666(srtA3) SGGB_2020(srtC2) SGGB_2153(srtA4) SGGB_2209(srtC3)
SMB: smi_1008(srtA)
SOR: SOR_0847(srtA) SOR_1066(srtG2) SOR_1067(srtG1)
STK: STP_0694(srtA)
STB: SGPB_0986(srtA) SGPB_1845(srtC)
SCF: Spaf_0023(srtB) Spaf_0978(srtA)
STF: Ssal_00905(srtA) Ssal_02063(srtB)
SIB: SIR_0082 SIR_0494(srtC) SIR_0811(srtA)
SIU: SII_0084 SII_0825(srtA)
SANG: SAIN_0973(srtA)
SANC: SANR_1049(srtA)
SCG: SCI_0960(srtA)
SCON: SCRE_0888(srtA)
SCOS: SCR2_0888(srtA)
SIK: K710_1067
LPL: lp_0514(srtA)
LPJ: JDM1_0416(srtA)
LPT: zj316_0658(srtA)
LPS: LPST_C0418(srtA)
LJO: LJ_1476
LJF: FI9785_791(srtA)
LJH: LJP_0753
LAC: LBA1244(srtA)
LAD: LA14_1249
LAF: SD55_1240(srtA)
LSA: LCA_0066(srtA1) LCA_1591(srtA2)
LSL: LSL_1606
LSI: HN6_01350
LSJ: LSJ_1662c
LDB: Ldb1310(srtA)
LBU: LBUL_1224
LBR: LVIS_0496
LCB: LCABL_05230(srt2) LCABL_06160(srtA) LCABL_23200(srtA) LCABL_25390(srt2)
LGA: LGAS_0825
LRE: Lreu_0236
LRF: LAR_0227
LRT: LRI_1722
LHE: lhv_1331
LHL: LBHH_0828
LHV: lhe_1261
LHH: LBH_1093
LHD: HUO_05455
LFE: LAF_0205
LFF: LBFF_0225
LRH: LGG_00441(srtC1) LGG_02143(srtA) LGG_02369(srtC2)
LRL: LC705_02150(srtA) LC705_02366(srtC2) LC705_p00020(srtA2)
LCR: LCRIS_01262(srtA)
LAM: LA2_07055
LBH: Lbuc_1581
LBN: LBUCD034_1639(srtA)
LRM: LRC_00630 LRC_16570(srtA)
LSN: LSA_05550
LAE: LBAT_1597
PPE: PEPE_1566
PPEN: T256_07730
EFL: EF62_0133(srtA) EF62_1545(srtC)
EFN: DENG_01230(srtA) DENG_02942(srtA)
MPS: MPTP_0053
MPX: MPD5_0048
OOE: OEOE_1443
LME: LEUM_0714
LMM: MI1_03260
WKO: WKK_02830
WCE: WS08_0848
WCT: WS74_0914
CRN: CAR_c15170(ywpE)
CML: BN424_1760 BN424_2317(srtA) BN424_2789(srtA) BN424_3051(srtB) BN424_3144(srtB) BN424_577(srtA)
CARC: NY10_835
CAC: CA_C0204(srta)
CAE: SMB_G0209(srta)
CAY: CEA_G0209(srta)
CTC: CTC_01198
CBO: CBO2133
CBA: CLB_2071
CBH: CLC_2076
CBY: CLM_2344
CBL: CLK_1590
CBB: CLD_2505
CBI: CLJ_B2340
CBF: CLI_2179
CBM: CBF_2163
CBV: U729_544(srtB) U729_752(srtB) U729_908
CSD: Clst_1279
RUS: RBI_I01263(yhcS) RBI_I01301(srtB) RBI_I01670 RBI_II00161(srtA) RBI_II00594(srtB2)
CPY: Cphy_0567
HSD: SD1D_1085
STH: STH2376
SLP: Slip_1253
DHD: Dhaf_4302
AWO: Awo_c20050(srtB)
SAY: TPY_1935 TPY_1993(srtA)
BPRM: CL3_30560
APR: Apre_1386
PMIC: NW74_06215
ERH: ERH_0013
CGL: NCgl2838(Cgl2939)
CEF: CE2738
CDP: CD241_0188(srtB) CD241_0190(srtC) CD241_1907(srtA) CD241_2114(srtE) CD241_2115(srtD)
CDH: CDB402_0154(srtB) CDB402_0156(srtC) CDB402_0200(srtD) CDB402_0201(srtE)
CDT: CDHC01_0190(srtB) CDHC01_0192(srtC) CDHC01_1909(srtA) CDHC01_2114(srtE) CDHC01_2115(srtD)
CDE: CDHC02_0191(srtB) CDHC02_0193(srtC) CDHC02_0238(srtD) CDHC02_0239(srtE) CDHC02_1898(srtA)
CDR: CDHC03_0157(srtC) CDHC03_0159(srtB) CDHC03_1886(srtA) CDHC03_2107(srtE) CDHC03_2108(srtH)
CDA: CDHC04_0146(srtB) CDHC04_0148(srtC) CDHC04_1885(srtA1) CDHC04_1925(srtA2) CDHC04_2135(srtE) CDHC04_2136(srtD)
CDZ: CD31A_0226(srtB) CD31A_0229(srtC) CD31A_0277(srtH) CD31A_0278(srtI)
CDB: CDBH8_0186(srtB) CDBH8_0188(srtC) CDBH8_1978(srtA)
CDS: CDC7B_0184(srtB) CDC7B_0186(srtC) CDC7B_0230(srtH) CDC7B_0231(srtI)
CDD: CDCE8392_0189(srtB) CDCE8392_0192(srtC) CDCE8392_1894(srtA)
CDW: CDPW8_0231(srtC1) CDPW8_1977(srtA3)
CDV: CDVA01_0139(srtB) CDVA01_0141(srtC) CDVA01_1843(srtA) CDVA01_2031(srtE) CDVA01_2032(srtD)
CJK: jk1700(srtA)
CUR: cu1897(srtB) cu1899(srtC)
CUA: CU7111_1828(srtB) CU7111_1830(srtC)
CAR: cauri_0189(srtD) cauri_0190(srtE)
CPU: cpfrc_01873(srtA) cpfrc_01875(srtB) cpfrc_01905(srtC)
CPL: Cp3995_1923(srtB) Cp3995_1926(srtA) Cp3995_1954(srtA)
CPG: Cp316_1929(srtB) Cp316_1957(srtA)
CPP: CpP54B96_1902(srtB) CpP54B96_1906(srtA) CpP54B96_1933(srtA)
CPK: Cp1002_1870(srtB) Cp1002_1874(srtA) Cp1002_1901(srtA)
CPQ: CpC231_1864(srtB) CpC231_1867(srtA) CpC231_1893(srtA)
CPX: CpI19_1881(srtB2) CpI19_1884(srtA2) CpI19_1914(srtA1)
CPZ: CpPAT10_1875(srtB) CpPAT10_1877(srtA) CpPAT10_1906(srtA)
COR: Cp267_1942(srtB) Cp267_1946(srtA) Cp267_1974(srtA)
COP: Cp31_1862(srtB1) Cp31_1864(srtA1) Cp31_1893(srtA2)
COD: Cp106_1830(srtB) Cp106_1857(srtA)
COS: Cp4202_1862(srtB) Cp4202_1866(srtA) Cp4202_1894(srtA)
COI: CpCIP5297_1891(srtB1) CpCIP5297_1928(srtA2) CpCIP5297_2274(srtA)
COE: Cp258_1886(srtB) Cp258_1888(srtA) Cp258_1918(srtA)
COU: Cp162_1847(srtB1) Cp162_1849(srtA1) Cp162_1878(srtA2)
CRD: CRES_0406(srtA) CRES_0409(srtB)
CUL: CULC22_02105(srtC) CULC22_02107(srtB) CULC22_02132(srtA)
CUC: CULC809_01951(srtC) CULC809_01953(srtB) CULC809_01981(srtA)
CUN: Cul210932_2079(srtB1) Cul210932_2083(srtA1) Cul210932_2112(srtA2)
CUS: CulFRC11_1968(srtB) CulFRC11_1970(srtA1) CulFRC11_1999(srtA2)
CUQ: Cul210931_2023(srtB1) Cul210931_2025(srtA1) Cul210931_2053(srtA2)
CUZ: Cul05146_2066(srtB1) Cul05146_2068(srtA1) Cul05146_2097(srtA2)
CKU: UL82_00220(srtE) UL82_08835(srtA) UL82_09760(srtD)
CCJ: UL81_00625(srtA) UL81_08785(srtB)
CEI: CEPID_10435(srtB) CEPID_10450(srtA)
SCO: SCO3850(SCH69.20c)
SALB: XNR_3035
SALS: SLNWT_3587
SLE: sle_35740(sle_35740)
STRD: NI25_19065
SALJ: SMD11_3459(srtA) SMD11_3462(srtA)
TWH: TWT_564
TWS: TW197
LXX: Lxx00190
CMI: CMM_0013
CMS: CMS0014(srtA)
CMC: CMN_00013
ART: Arth_0017
ACH: Achl_0017
BCV: Bcav_0035
JDE: Jden_0283
XCE: Xcel_1522
IDO: I598_2491
CFI: Celf_0026
SERJ: SGUI_2616
PFR: PFREUD_19210(srtA) PFREUD_19740(srt)
KFL: Kfla_2014
PSIM: KR76_19920
TFU: Tfu_2383
NDA: Ndas_0374
NAL: B005_3241
TCU: Tcur_0060
FAL: FRAAL2033
ACE: Acel_0016
GOB: Gobs_0134
MMAR: MODMU_0327
AMD: AMED_7360(srtA)
AMN: RAM_37835
AMM: AMES_7249(srtA)
AMZ: B737_7249(srtA)
AOI: AORI_1802(srtA)
AJA: AJAP_30485(srtA)
AFS: AFR_00310
SNA: Snas_6133
AHE: Arch_0229
BLJ: BLD_1287(srtA1) BLD_1469(srtA4)
BLN: Blon_0162
BLON: BLIJ_0166
BLL: BLJ_0146
BLB: BBMN68_1231(srtA1) BBMN68_1406(srtA4) BBMN68_437
BLV: BalV_1306(srtB) BalV_1440
BBF: BBB_0267(srtA) BBB_0814 BBB_1709(srtA) BBB_1818(srtA)
BAST: BAST_0371
SIJ: SCIP_0159
RXY: Rxyl_2899
CAU: Caur_0431
CAG: Cagg_3111
HAU: Haur_4642
STI: Sthe_2655
ATM: ANT_23120
NDE: NIDE0940
NJA: NSJP_1967
MTH: MTH_1829
METC: MTCT_1669
METE: tca_01767
METH: MBMB1_1336
MCUB: MCBB_1576
MFV: Mfer_0746
MKA: MK0158(srtA)
 » show all
Taxonomy
Reference
1  [PMID:10535938]
  Authors
Ton-That H, Liu G, Mazmanian SK, Faull KF, Schneewind O
  Title
Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 12424-9.
Reference
2  [PMID:15117963]
  Authors
Zong Y, Bice TW, Ton-That H, Schneewind O, Narayana SV
  Title
Crystal structures of Staphylococcus aureus sortase A and its substrate complex.
  Journal
J. Biol. Chem. 279 (2004) 31383-9.
Reference
3  [PMID:19129180]
  Authors
Race PR, Bentley ML, Melvin JA, Crow A, Hughes RK, Smith WD, Sessions RB, Kehoe MA, McCafferty DG, Banfield MJ
  Title
Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism.
  Journal
J. Biol. Chem. 284 (2009) 6924-33.
  Sequence
[spy:SPy_1154]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.70
IUBMB Enzyme Nomenclature: 3.4.22.70
ExPASy - ENZYME nomenclature database: 3.4.22.70
BRENDA, the Enzyme Database: 3.4.22.70

DBGET integrated database retrieval system