KEGG   ENZYME: 3.4.23.16Help
Entry
EC 3.4.23.16                Enzyme                                 

Name
HIV-1 retropepsin;
human immunodeficiency virus type 1 protease;
gag protease;
HIV aspartyl protease;
HIV proteinase;
retroproteinase;
HIV-1 protease;
HIV-2 protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro
Comment
Present in human immunodeficiency virus type 1. Contributes to the maturation of the viral particle, and is a target of antiviral drugs. Active enzyme is a dimer of identical 11-kDa subunits. Similar enzymes occur in other retroviruses [1]. Type example of peptidase family A2
Reference
1
  Authors
Kuo, L.C. and Shafer, J.A.
  Title
(eds) Retroviral Proteases.
  Journal
Methods Enzymol. 241 (1994) 1-431.
Reference
2
  Authors
Dunn, B.M.
  Title
Human immunodeficiency virus 1 retropepsin.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 919-928.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
144114-21-6

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