KEGG   ENZYME: 3.4.23.23Help
Entry
EC 3.4.23.23                Enzyme                                 

Name
mucorpepsin;
Mucor rennin;
Mucor aspartic proteinase;
Mucor acid proteinase;
Mucor acid protease;
Mucor miehei aspartic proteinase;
Mucor miehei aspartic protease;
Mucor aspartic proteinase;
Mucor pusillus emporase;
Fromase 100;
Mucor pusillus rennin;
Fromase 46TL;
Mucor miehei rennin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins, favouring hydrophobic residues at P1 and P1'. Clots milk. Does not accept Lys at P1, and hence does not activate trypsinogen
Comment
Isolated from the zygomycete fungi Mucor pusillus and M. miehei. The two species variants show 83% sequence identity and are immunologically crossreactive. In peptidase family A1 (pepsin A family). Formerly included in EC 3.4.23.6
History
EC 3.4.23.23 created 1992 (EC 3.4.23.6 created 1992 (EC 3.4.23.6 created 1961 as EC 3.4.4.17, transferred 1972 to EC 3.4.23.6, modified 1981 [EC 3.4.23.7, EC 3.4.23.8, EC 3.4.23.9, EC 3.4.23.10, EC 3.4.99.1, EC 3.4.99.15 and EC 3.4.99.25 all created 1972 and incorporated 1978], part incorporated 1992)
Orthology
K01386  
mucorpepsin
Reference
1
  Authors
Arima, K., Yu, J. and Iwasaki, S.
  Title
Milk-clotting enzyme from Mucor pusillus var. lindt.
  Journal
Methods Enzymol. 19 (1970) 446-459.
Reference
2
  Authors
Ottesen, M. and Rickert, W.
  Title
The acid protease of Mucor miehei.
  Journal
Methods Enzymol. 19 (1970) 459-460.
Reference
3  [PMID:4573298]
  Authors
Sternberg M.
  Title
Bond specificity, active site and milk clotting mechanism of the Mucor miehei protease.
  Journal
Biochim. Biophys. Acta. 285 (1972) 383-92.
Reference
4
  Authors
Oka, T., Ishino, K., Tsuzuki, H., Morihara, K. and Arima, K.
  Title
On the specificity of a rennin-like enzyme from Mucor pusillus.
  Journal
Agric. Biol. Chem. 37 (1973) 1177-1184.
Reference
5  [PMID:3042459]
  Authors
Baudys M, Foundling S, Pavlik M, Blundell T, Kostka V.
  Title
Protein chemical characterization of Mucor pusillus aspartic proteinase. Amino acid sequence homology with the other aspartic proteinases, disulfide bond arrangement and site of carbohydrate attachment.
  Journal
FEBS. Lett. 235 (1988) 271-4.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
148465-73-0

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