KEGG   ENZYME: 3.4.23.25Help
Entry
EC 3.4.23.25                Enzyme                                 

Name
saccharopepsin;
yeast endopeptidase A;
Saccharomyces aspartic proteinase;
aspartic proteinase yscA;
proteinase A;
proteinase yscA;
yeast proteinase A;
Saccharomyces cerevisiae aspartic proteinase A;
yeast proteinase A;
PRA
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu!Val-Tyr bond in a synthetic substrate. Does not act on esters of Tyr or Arg
Comment
Located in the vacuole of the baker's yeast (Saccharomyces cerevisiae) cell. In peptidase family A1 (pepsin A family).
History
EC 3.4.23.25 created 1992 (EC 3.4.23.6 created 1992 (EC 3.4.23.6 created 1961 as EC 3.4.4.17, transferred 1972 to EC 3.4.23.6, modified 1981 [EC 3.4.23.7, EC 3.4.23.8, EC 3.4.23.9, EC 3.4.23.10, EC 3.4.99.1, EC 3.4.99.15 and EC 3.4.99.25 all created 1972 and incorporated 1978], part incorporated 1992)
Orthology
K01381  
saccharopepsin
Genes
TSP: 
SMO: 
SCE: 
YPL154C(PEP4)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0C01360(NCAS0C01360)
NDI: 
NDAI_0E02105(NDAI0E02105)
TPF: 
TPHA_0D01260(TPHA0D01260)
TBL: 
TBLA_0B03830(TBLA0B03830)
TDL: 
TDEL_0A06230(TDEL0A06230)
KAF: 
KAFR_0H02420(KAFR0H02420)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
NCU02273(pep4)
NTE: 
NEUTE1DRAFT117869(NEUTE1DRAFT_117869)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1220154(AO090003000693)
ANG: 
ANI_1_994024(An02g07210)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT113304(AGABI1DRAFT_113304)
ABV: 
AGABI2DRAFT192052(AGABI2DRAFT_192052)
CPUT: 
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
TET: 
PTM: 
SMIN: 
v1.2.015207.t1(symbB.v1.2.015207.t1)
PIF: 
 » show all
Taxonomy
Reference
1
  Authors
Hata, T., Hayashi, R. and Dot, E.
  Title
Purification of yeast proteinases. Part III. Isolation and physicochemical properties of yeast proteinase A and C.
  Journal
Agric. Biol. Chem. 31 (1967) 357-367.
Reference
2  [PMID:7002931]
  Authors
Meussdoerffer F, Tortora P, Holzer H.
  Title
Purification and properties of proteinase A from yeast.
  Journal
J. Biol. Chem. 255 (1980) 12087-93.
Reference
3  [PMID:3023936]
  Authors
Ammerer G, Hunter CP, Rothman JH, Saari GC, Valls LA, Stevens TH.
  Title
PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors.
  Journal
Mol. Cell. Biol. 6 (1986) 2490-9.
  Sequence
[sce:YPL154C]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37228-80-1

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