KEGG   ENZYME: 3.4.23.25Help
Entry
EC 3.4.23.25                Enzyme                                 

Name
saccharopepsin;
yeast endopeptidase A;
Saccharomyces aspartic proteinase;
aspartic proteinase yscA;
proteinase A;
proteinase yscA;
yeast proteinase A;
Saccharomyces cerevisiae aspartic proteinase A;
yeast proteinase A;
PRA
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu!Val-Tyr bond in a synthetic substrate. Does not act on esters of Tyr or Arg
Comment
Located in the vacuole of the baker's yeast (Saccharomyces cerevisiae) cell. In peptidase family A1 (pepsin A family).
History
EC 3.4.23.25 created 1992 (EC 3.4.23.6 created 1992 (EC 3.4.23.6 created 1961 as EC 3.4.4.17, transferred 1972 to EC 3.4.23.6, modified 1981 [EC 3.4.23.7, EC 3.4.23.8, EC 3.4.23.9, EC 3.4.23.10, EC 3.4.99.1, EC 3.4.99.15 and EC 3.4.99.25 all created 1972 and incorporated 1978], part incorporated 1992)
Orthology
K01381  saccharopepsin
Genes
NAI: NECAME_00427 NECAME_02619 NECAME_06158 NECAME_15831
TSP: Tsp_11629
OVI: T265_01702 T265_09453 T265_09454 T265_11571 T265_11760 T265_11819 T265_13674 T265_13680 T265_13694
EUS: EUTSA_v10017686mg EUTSA_v10017850mg EUTSA_v10017857mg
BNA: 106345535 106364205 106389856 106435548
BOE: 106293064 106293878
CIT: 102618445 102619023 102623581 102624679
CIC: CICLE_v10025623mg CICLE_v10031639mg
TCC: 18587669 18589378 18602110
GRA: 105770676 105793727
EGR: 104454535
VRA: 106776889
LJA: Lj0g3v0316769.1(Lj0g3v0316769.1) Lj0g3v0360319.1(Lj0g3v0360319.1) Lj3g3v0950710.1(Lj3g3v0950710.1)
PPER: 18788058
PMUM: 103327300
MDM: 103438621
CSV: 101202903
CMO: 103485161
JCU: 105646088
HBR: 110671270
JRE: 109016459
VVI: 100245570
SOT: 102599987
NSY: 104221729
SOE: 110804227
ATS: 109743306(LOC109743306)
SBI: 8082436
ZMA: 100382248
AOF: 109823111
SCE: YPL154C(PEP4)
ERC: Ecym_2396
KMX: KLMA_70025(PEP4)
NCS: NCAS_0C01360(NCAS0C01360)
NDI: NDAI_0E02105(NDAI0E02105)
TPF: TPHA_0D01260(TPHA0D01260)
TBL: TBLA_0B03830(TBLA0B03830)
TDL: TDEL_0A06230(TDEL0A06230)
KAF: KAFR_0H02420(KAFR0H02420)
PIC: PICST_73446(APR1)
CAL: CAALFM_C207400CA(APR1)
CAUR: QG37_07299
SLB: AWJ20_3869(PEP4)
NCR: NCU02273(pep4)
NTE: NEUTE1DRAFT117869(NEUTE1DRAFT_117869)
MGR: MGG_00922
MAW: MAC_01466
MAJ: MAA_04936
CMT: CCM_03813
BFU: BCIN_02g08590(Bcap2)
MBE: MBM_06769
ANI: AN2903.2
ANG: ANI_1_994024(An02g07210)
ABE: ARB_02919
TVE: TRV_05606
CNE: CNA05650
CNB: CNBA5450
ABP: AGABI1DRAFT113304(AGABI1DRAFT_113304) AGABI1DRAFT113487(AGABI1DRAFT_113487)
ABV: AGABI2DRAFT191864(AGABI2DRAFT_191864) AGABI2DRAFT192052(AGABI2DRAFT_192052)
MGL: MGL_3195
PYO: PY17X_1036800(PY06899)
SMIN: v1.2.015207.t1(symbB.v1.2.015207.t1)
SPAR: SPRG_10505
 » show all
Taxonomy
Reference
1
  Authors
Hata, T., Hayashi, R. and Dot, E.
  Title
Purification of yeast proteinases. Part III. Isolation and physicochemical properties of yeast proteinase A and C.
  Journal
Agric. Biol. Chem. 31 (1967) 357-367.
Reference
2  [PMID:7002931]
  Authors
Meussdoerffer F, Tortora P, Holzer H.
  Title
Purification and properties of proteinase A from yeast.
  Journal
J. Biol. Chem. 255 (1980) 12087-93.
Reference
3  [PMID:3023936]
  Authors
Ammerer G, Hunter CP, Rothman JH, Saari GC, Valls LA, Stevens TH.
  Title
PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors.
  Journal
Mol. Cell. Biol. 6 (1986) 2490-9.
  Sequence
[sce:YPL154C]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.25
IUBMB Enzyme Nomenclature: 3.4.23.25
ExPASy - ENZYME nomenclature database: 3.4.23.25
BRENDA, the Enzyme Database: 3.4.23.25
CAS: 37228-80-1

DBGET integrated database retrieval system