KEGG   ENZYME: 3.4.23.31Help
Entry
EC 3.4.23.31                Enzyme                                 

Name
scytalidopepsin A;
Scytalidium aspartic proteinase A;
Scytalidium lignicolum aspartic proteinase;
Scytalidium lignicolum aspartic proteinase A-2;
Scytalidium lignicolum aspartic proteinase A-I;
Scytalidium lignicolum aspartic proteinase C;
Scytalidium lignicolum carboxyl proteinase;
Scytalidium lignicolum acid proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins with specificity similar to that of pepsin A, but also cleaves Cys(SO3H)7!Gly and Leu17!Val in the B chain of insulin
Comment
Isolated from the imperfect fungus Scytalidium lignicolum. Not inhibited by pepstatin-Ac, methyl 2-diazoacetamidohexanoate or 1,2-epoxy-3-(p-nitrophenyl)propane. A related enzyme from the same organism, proteinase C, is also insensitive to these inhibitors and has Mr = 406,000 [3]
History
EC 3.4.23.31 created 1992
Reference
1
  Authors
Oda, K. and Murao, S.
  Title
Purification and some enzymatic properties of acid protease A and B of Scytalidium lignicolum ATCC 24568.
  Journal
Agric. Biol. Chem. 38 (1974) 2435-2444.
Reference
2
  Authors
Oda, K. and Murao, S.
  Title
Action of Scytalidium lignicolum acid proteases on insulin B-chain.
  Journal
Agric. Biol. Chem. 40 (1976) 1221-1225.
Reference
3
  Authors
Oda, K., Torishima, H. and Murao, S.
  Title
Purification and characterization of acid proteinase C of Scytalidium lignicolum ATCC 24568.
  Journal
Agric. Biol. Chem. 50 (1986) 651-658.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
42613-34-3

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