KEGG   ENZYME: 3.4.23.34Help
Entry
EC 3.4.23.34                Enzyme                                 

Name
cathepsin E;
slow-moving proteinase;
erythrocyte membrane aspartic proteinase;
SMP;
erythrocyte membrane aspartic proteinase;
EMAP;
non-pepsin proteinase;
cathepsin D-like acid proteinase;
cathepsin E-like acid proteinase;
cathepsin D-type proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Similar to cathepsin D, but slightly broader specificity
Comment
Found in stomach, spleen, erythrocyte membrane; not lysosomal. Pro-cathepsin E is an 86 kDa disulfide-linked dimer; activation or reduction produces monomer. In peptidase family A1 (pepsin A family)
History
EC 3.4.23.34 created 1992
Orthology
K01382  
cathepsin E
Genes
HSA: 
1510(CTSE)
PTR: 
457677(CTSE)
PPS: 
100996015(CTSE)
GGO: 
101124402(CTSE)
PON: 
100452388(CTSE)
NLE: 
100603573(CTSE)
MCC: 
696202(CTSE)
MCF: 
102122689(CTSE)
CSAB: 
103230206(CTSE)
RRO: 
104661729(CTSE)
CJC: 
100413525(CTSE)
SBQ: 
101046996(CTSE)
MMU: 
13034(Ctse)
RNO: 
25424(Ctse)
CGE: 
100757212(Ctse)
NGI: 
103725942(Ctse)
HGL: 
101699894(Ctse)
OCU: 
100009063(CTSE)
TUP: 
102483572(CTSE)
CFA: 
488577(CTSE)
AML: 
100475014(CTSE)
UMR: 
103671000(CTSE)
FCA: 
101088455(CTSE)
PTG: 
102960694(CTSE)
AJU: 
106972890(CTSE)
BOM: 
106701532(CTSE)
SSC: 
102160195(CTSE)
ECB: 
100055161(CTSE)
MYB: 
102250825(CTSE)
MYD: 
102753719(CTSE)
HAI: 
109386433(CTSE)
PALE: 
102890366(CTSE)
LAV: 
100663037(CTSE)
MDO: 
100019361(CTSE)
SHR: 
100934264(CTSE)
GGA: 
771791(CTSE)
MGP: 
100548063(CTSE)
CJO: 
107324888(CTSE)
APLA: 
101789387(CTSE)
TGU: 
100228499(CTSE)
GFR: 
102043260(CTSE)
FAB: 
101815239(CTSE)
PHI: 
102104842(CTSE)
CCW: 
104692361(CTSE)
FPG: 
101920453(CTSE)
FCH: 
102051110(CTSE)
CLV: 
102089416(CTSE)
AAM: 
106484553(CTSE)
ASN: 
102384944(CTSE)
AMJ: 
102567770(CTSE)
PSS: 
102463529(CTSE)
CMY: 
102931323(CTSE)
CPIC: 
101933009(CTSE) 101941871
ACS: 
100561705(ctse) 100561900
PBI: 
103067272(CTSE)
GJA: 
107115330(CTSE)
XLA: 
373572(ctse.L) 373573(ctse.S)
XTR: 
100145572(ctse)
XMA: 
102238257
LCM: 
102345230(CTSE)
CMK: 
103185314(ctse)
CSL: 
COCSUDRAFT_55151 COCSUDRAFT_62232
PCO: 
PHACADRAFT_248326 PHACADRAFT_80588
HIR: 
HETIRDRAFT_99524
PSQ: 
PUNSTDRAFT_72737
ADL: 
AURDEDRAFT_169434 AURDEDRAFT_170430
FME: 
FOMMEDRAFT_160284
MRR: 
Moror_14679
ABV: 
AGABI2DRAFT211096(AGABI2DRAFT_211096)
MLR: 
MELLADRAFT_65252
PTM: 
GSPATT00010671001 GSPATT00012501001 GSPATT00016271001 GSPATT00019552001
SMIN: 
v1.2.003841.t1(symbB.v1.2.003841.t1) v1.2.015387.t1(symbB.v1.2.015387.t1) v1.2.018093.t1(symbB.v1.2.018093.t1) v1.2.018143.t1(symbB.v1.2.018143.t1) v1.2.018682.t1(symbB.v1.2.018682.t1) v1.2.018682.t2(symbB.v1.2.018682.t2) v1.2.022081.t1(symbB.v1.2.022081.t1) v1.2.024260.t1(symbB.v1.2.024260.t1)
PIF: 
PITG_04975
PSOJ: 
PHYSODRAFT_324695
 » show all
Taxonomy
Reference
1  [PMID:3741628]
  Authors
Lapresle C, Puizdar V, Porchon-Bertolotto C, Joukoff E, Turk V.
  Title
Structural differences between rabbit cathepsin E and cathepsin D.
  Journal
Biol. Chem. Hoppe. Seyler. 367 (1986) 523-6.
Reference
2  [PMID:3058036]
  Authors
Yonezawa S, Fujii K, Maejima Y, Tamoto K, Mori Y, Muto N.
  Title
Further studies on rat cathepsin E: subcellular localization and existence of the active subunit form.
  Journal
Arch. Biochem. Biophys. 267 (1988) 176-83.
Reference
3  [PMID:3058118]
  Authors
Jupp RA, Richards AD, Kay J, Dunn BM, Wyckoff JB, Samloff IM, Yamamoto K.
  Title
Identification of the aspartic proteinases from human erythrocyte membranes and gastric mucosa (slow-moving proteinase) as catalytically equivalent to cathepsin E.
  Journal
Biochem. J. 254 (1988) 895-8.
Reference
4  [PMID:2674141]
  Authors
Azuma T, Pals G, Mohandas TK, Couvreur JM, Taggart RT.
  Title
Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases.
  Journal
J. Biol. Chem. 264 (1989) 16748-53.
  Sequence
[hsa:1510]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
110910-42-4
DBGET integrated database retrieval system