KEGG   ENZYME: 3.4.23.34Help
Entry
EC 3.4.23.34                Enzyme                                 

Name
cathepsin E;
slow-moving proteinase;
erythrocyte membrane aspartic proteinase;
SMP;
erythrocyte membrane aspartic proteinase;
EMAP;
non-pepsin proteinase;
cathepsin D-like acid proteinase;
cathepsin E-like acid proteinase;
cathepsin D-type proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Similar to cathepsin D, but slightly broader specificity
Comment
Found in stomach, spleen, erythrocyte membrane; not lysosomal. Pro-cathepsin E is an 86 kDa disulfide-linked dimer; activation or reduction produces monomer. In peptidase family A1 (pepsin A family)
History
EC 3.4.23.34 created 1992
Orthology
K01382  cathepsin E
Genes
HSA: 1510(CTSE)
PTR: 457677(CTSE)
PPS: 100996015(CTSE)
GGO: 101124402(CTSE)
PON: 100452388(CTSE)
NLE: 100603573(CTSE)
MCC: 696202(CTSE)
MCF: 102122689(CTSE)
CSAB: 103230206(CTSE)
RRO: 104661729(CTSE)
RBB: 108535115(CTSE)
CJC: 100413525(CTSE)
SBQ: 101046996(CTSE)
MMU: 13034(Ctse)
RNO: 25424(Ctse)
CGE: 100757212(Ctse)
NGI: 103725942(Ctse)
HGL: 101699894(Ctse)
CCAN: 109697219(Ctse)
OCU: 100009063(CTSE)
TUP: 102483572(CTSE)
CFA: 488577(CTSE)
AML: 100475014(CTSE)
UMR: 103671000(CTSE)
ORO: 101364641(CTSE)
FCA: 101088455(CTSE)
PTG: 102960694(CTSE)
AJU: 106972890(CTSE)
BOM: 106701532(CTSE)
OOR: 105748678(CTSE)
ECB: 100055161(CTSE)
EPZ: 103553838(CTSE)
EAI: 106823465(CTSE)
MYB: 102250825(CTSE)
MYD: 102753719(CTSE)
HAI: 109386433(CTSE)
RSS: 109458634(CTSE)
PALE: 102890366(CTSE)
LAV: 100663037(CTSE)
TMU: 101345963
MDO: 100019361(CTSE)
SHR: 100934264(CTSE)
GGA: 771791(CTSE)
MGP: 100548063(CTSE)
CJO: 107310248 107324888(CTSE)
APLA: 101789387(CTSE) 101804173
ACYG: 106041279(CTSE) 106045567
TGU: 100228499(CTSE)
GFR: 102041269 102043260(CTSE)
FAB: 101814202 101815239(CTSE)
PHI: 102101700 102104842(CTSE)
PMAJ: 107205210 107214812(CTSE)
CCW: 104692361(CTSE) 104698380
FPG: 101920453(CTSE) 101923255
FCH: 102049037 102051110(CTSE)
CLV: 102089416(CTSE) 102097331
EGZ: 104132915 104134468(CTSE)
AAM: 106484553(CTSE) 106488475
ASN: 102380654 102384944(CTSE)
AMJ: 102566566(NOTS) 102567770(CTSE)
PSS: 102461548 102463529(CTSE)
CMY: 102931323(CTSE) 102933016
CPIC: 101933009(CTSE) 101941871
ACS: 100561705(ctse) 100561900
PVT: 110081416(CTSE)
PBI: 103067272(CTSE)
GJA: 107105702 107115330(CTSE)
XLA: 373572(ctse.L) 373573(ctse.S)
XTR: 100145572(ctse)
NPR: 108787647(CTSE) 108804543
SRX: 107725781
SANH: 107677818
SGH: 107569115
CCAR: 109062605
IPU: 108279983
AMEX: 103036771
TRU: 777958(nts)
LCO: 104935800
MZE: 101475107
OLA: 101159061
XMA: 102238257
PRET: 103459337
NFU: 107387581
LCF: 108901352
HCQ: 109532693
BPEC: 110161516
SASA: 106576650
ELS: 105023104
LCM: 102345230(CTSE)
CMK: 103185314(ctse)
DSI: Dsimw501_GD29212(Dsim_GD29212)
BRP: 103841663
BNA: 106364978
ADU: 107466838
CMT: CCM_00473
ABP: AGABI1DRAFT130075(AGABI1DRAFT_130075)
ABV: AGABI2DRAFT211096(AGABI2DRAFT_211096)
SMIN: v1.2.003841.t1(symbB.v1.2.003841.t1) v1.2.015387.t1(symbB.v1.2.015387.t1) v1.2.018093.t1(symbB.v1.2.018093.t1) v1.2.018143.t1(symbB.v1.2.018143.t1) v1.2.018682.t1(symbB.v1.2.018682.t1) v1.2.018682.t2(symbB.v1.2.018682.t2) v1.2.022081.t1(symbB.v1.2.022081.t1) v1.2.024260.t1(symbB.v1.2.024260.t1) v1.2.037886.t1(symbB.v1.2.037886.t1)
 » show all
Taxonomy
Reference
1  [PMID:3741628]
  Authors
Lapresle C, Puizdar V, Porchon-Bertolotto C, Joukoff E, Turk V.
  Title
Structural differences between rabbit cathepsin E and cathepsin D.
  Journal
Biol. Chem. Hoppe. Seyler. 367 (1986) 523-6.
Reference
2  [PMID:3058036]
  Authors
Yonezawa S, Fujii K, Maejima Y, Tamoto K, Mori Y, Muto N.
  Title
Further studies on rat cathepsin E: subcellular localization and existence of the active subunit form.
  Journal
Arch. Biochem. Biophys. 267 (1988) 176-83.
Reference
3  [PMID:3058118]
  Authors
Jupp RA, Richards AD, Kay J, Dunn BM, Wyckoff JB, Samloff IM, Yamamoto K.
  Title
Identification of the aspartic proteinases from human erythrocyte membranes and gastric mucosa (slow-moving proteinase) as catalytically equivalent to cathepsin E.
  Journal
Biochem. J. 254 (1988) 895-8.
Reference
4  [PMID:2674141]
  Authors
Azuma T, Pals G, Mohandas TK, Couvreur JM, Taggart RT.
  Title
Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases.
  Journal
J. Biol. Chem. 264 (1989) 16748-53.
  Sequence
[hsa:1510]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.34
IUBMB Enzyme Nomenclature: 3.4.23.34
ExPASy - ENZYME nomenclature database: 3.4.23.34
BRENDA, the Enzyme Database: 3.4.23.34
CAS: 110910-42-4

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