KEGG   ENZYME: 3.4.23.42Help
Entry
EC 3.4.23.42                Enzyme                                 

Name
thermopsin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Similar in specificity to pepsin A preferring bulky hydrophobic amino acids in P1 and P1'
Comment
From the thermophilic archaeon Sulfolobus acidocaldarius. Maximally active at pH 2 and 90 _degree_C. Weakly inhibited by pepstatin but shows no sequence similarity to pepsin. Type example of peptidase family A5.
History
EC 3.4.23.42 created 1992 as EC 3.4.99.43, transferred 2000 to EC 3.4.23.42
Orthology
K01385  thermopsin
Genes
TAC: Ta0167
TVO: TVG0251055(TVG0251055)
PTO: PTO0161 PTO1487
SSO: SSO1886 SSO2037 SSO2045 SSO2194
SOL: Ssol_2683
SSOA: SULA_2704
SSOL: SULB_2705
SSOF: SULC_2702
SAI: Saci_1049 Saci_1534 Saci_1714(thpS) Saci_2170
SACN: SacN8_08325
SID: M164_0728
SII: LD85_0747
SIH: SiH_0641
SIR: SiRe_0691
SIC: SiL_0729
CMA: Cmaq_1218
TUZ: TUZN_1549
TTN: TTX_0358(thpS)
TPE: Tpen_1285
 » show all
Taxonomy
Reference
1  [PMID:7674919]
  Authors
Lin X, Tang J.
  Title
Thermopsin.
  Journal
Methods. Enzymol. 248 (1995) 156-68.
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.42
IUBMB Enzyme Nomenclature: 3.4.23.42
ExPASy - ENZYME nomenclature database: 3.4.23.42
BRENDA, the Enzyme Database: 3.4.23.42
CAS: 126125-05-1

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