KEGG   ENZYME: 3.4.23.44Help
Entry
EC 3.4.23.44                Enzyme                                 

Name
nodavirus endopeptidase;
Black Beetle virus endopeptidase;
Flock House virus endopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of an asparaginyl bond involved in the maturation of the structural protein of the virus, typically -Asn!Ala- or -Asn!Phe-
Comment
A single aspartic residue is critical for activity, and inhibition by EDTA indicates that a metal ion is also important. The enzyme is known from several nodaviruses that are pathogens of insects. Type example of peptidase family A6, and structurally related to the tetravirus endopeptidase in family A21, although in that family, the catalytic residue is thought to be Glu.
History
EC 3.4.23.44 created 2001
Reference
1  [PMID:8175803]
  Authors
Zlotnick A, Reddy VS, Dasgupta R, Schneemann A, Ray WJ Jr, Rueckert RR, Johnson JE.
  Title
Capsid assembly in a family of animal viruses primes an autoproteolytic maturation that depends on a single aspartic acid residue.
  Journal
J. Biol. Chem. 269 (1994) 13680-4.
Reference
2
  Authors
Johnson, J.E. and Schneemann, A.
  Title
Nodavirus endopeptidase.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Handbook of Proteolytic Enzymes, London, 1998, p. 964-967.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
852954-38-2

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