KEGG   ENZYME: 3.4.23.45Help
Entry
EC 3.4.23.45                Enzyme                                 

Name
memapsin 1;
beta-secretase;
beta-site Alzheimer's amyloid precursor protein cleaving enzyme 2 (BACE2);
ASP1;
Down region aspartic protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu!Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein
Comment
Can cleave beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease, but is not significantly expressed in human brain. In peptidase family A1, but is atypical in containing a C-terminal membrane-spanning domain.
History
EC 3.4.23.45 created 2003
Orthology
K07747  beta-site APP-cleaving enzyme 2 (memapsin 1)
Genes
HSA: 25825(BACE2)
PTR: 747819(BACE2)
PPS: 100990201(BACE2)
GGO: 101131488(BACE2)
PON: 100442149(BACE2)
NLE: 100598433(BACE2)
MCC: 715330(BACE2)
MCF: 102140609(BACE2)
CSAB: 103219113(BACE2)
RRO: 104655130(BACE2)
RBB: 108534721(BACE2)
CJC: 100406072(BACE2)
SBQ: 101041728(BACE2)
MMU: 56175(Bace2)
RNO: 288227(Bace2)
CGE: 100764950(Bace2)
NGI: 103748454(Bace2)
HGL: 101717943(Bace2)
CCAN: 109675235
OCU: 100342092(BACE2)
TUP: 102498668(BACE2)
CFA: 478418(BACE2)
AML: 100477612(BACE2)
UMR: 103680727(BACE2)
ORO: 101382461(BACE2)
FCA: 101096756(BACE2)
PTG: 102955826(BACE2)
AJU: 106965624(BACE2)
BTA: 534774(BACE2)
BOM: 102272554(BACE2)
BIU: 109560497(BACE2)
PHD: 102317728(BACE2)
CHX: 102187812(BACE2)
OAS: 101102027(BACE2)
SSC: 100517374(BACE2)
CFR: 102516803(BACE2)
CDK: 105099560(BACE2)
BACU: 103014984(BACE2)
LVE: 103085141(BACE2)
OOR: 101276476(BACE2)
ECB: 100058700(BACE2)
EPZ: 103563066(BACE2)
EAI: 106829946(BACE2)
MYB: 102254769(BACE2)
MYD: 102767911(BACE2)
HAI: 109372661(BACE2)
RSS: 109454783(BACE2)
PALE: 102896199(BACE2)
LAV: 100653591(BACE2)
TMU: 101360622
MDO: 100016587(BACE2)
SHR: 100932104(BACE2)
OAA: 100080196(BACE2)
GGA: 418526(BACE2)
MGP: 100547969(BACE2)
CJO: 107323138(BACE2)
APLA: 101795939(BACE2)
ACYG: 106036113(BACE2)
TGU: 100224177(BACE2)
GFR: 102039028(BACE2)
FAB: 101816221(BACE2)
PHI: 102107969(BACE2)
PMAJ: 107212623(BACE2)
CCW: 104686367(BACE2)
FPG: 101919630(BACE2)
FCH: 102051138(BACE2)
CLV: 102088959(BACE2)
EGZ: 104128185(BACE2)
AAM: 106494905(BACE2)
ASN: 102386120(BACE2)
AMJ: 102561959(BACE2)
PSS: 102447109(BACE2)
CMY: 102940897(BACE2)
CPIC: 101938324(BACE2)
ACS: 100552914(bace2)
PVT: 110076824(BACE2)
PBI: 103059516(BACE2)
GJA: 107124625(BACE2)
XLA: 380307(bace2.L) 398806(bace2.S)
XTR: 100216145(bace2)
NPR: 108783971(BACE2)
DRE: 449818(bace2)
IPU: 108280663
AMEX: 103044755
TRU: 101078612(bace2)
LCO: 104921140(bace2)
NCC: 104967128(bace2)
MZE: 101466632
OLA: 101167562
XMA: 102236423
PRET: 103474388
NFU: 107380543(bace2)
CSEM: 103377589(bace2)
LCF: 108873776(bace2)
HCQ: 109512909
BPEC: 110171890(bace2)
ELS: 105021658(bace2)
SFM: 108932129
LCM: 102362842(BACE2)
CMK: 103187270(bace2)
ADF: 107356607
SPAR: SPRG_07185
 » show all
Taxonomy
Reference
1  [PMID:12093293]
  Authors
Turner RT 3rd, Loy JA, Nguyen C, Devasamudram T, Ghosh AK, Koelsch G, Tang J.
  Title
Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity.
  Journal
Biochemistry. 41 (2002) 8742-6.
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.45
IUBMB Enzyme Nomenclature: 3.4.23.45
ExPASy - ENZYME nomenclature database: 3.4.23.45
BRENDA, the Enzyme Database: 3.4.23.45
CAS: 447457-31-0

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