KEGG   ENZYME: 3.4.23.48Help
Entry
EC 3.4.23.48                Enzyme                                 

Name
plasminogen activator Pla
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Converts human Glu-plasminogen to plasmin by cleaving the Arg560!Val peptide bond that is also hydrolysed by the mammalian u-plasminogen activator and t-plasminogen activator. Also cleaves arginyl bonds in other proteins
Comment
In peptidase family A26. From the bacterium Yersinia pestis that causes plague.
History
EC 3.4.23.48 created 2003
Orthology
K08566  
plasminogen activator
Genes
YPE: 
YPA: 
YPN: 
YPM: 
YPG: 
YPZ: 
YPT: 
YPD: 
YPX: 
YPH: 
YPW: 
YPJ: 
YPV: 
YPL: 
PEC: 
EPY: 
EPR: 
ERJ: 
EGE: 
ENT: 
ENC: 
EEC: 
ENL: 
ECLG: 
ESA: 
CSZ: 
CUI: 
KPE: 
KPK_A0239(ompT)
KOX: 
KOE: 
KOY: 
KOK: 
KOM: 
KMI: 
SERF: 
XDO: 
PLF: 
PAQ: 
PVA: 
PAO: 
PAGG: 
RON: 
CNT: 
CEM: 
CEN: 
KSA: 
VCY: 
VCT: 
DSF: 
OAH: 
TSU: 
TBE: 
SFC: 
 » show all
Taxonomy
Reference
1  [PMID:11401715]
  Authors
Kukkonen M, Lahteenmaki K, Suomalainen M, Kalkkinen N, Emody L, Lang H, Korhonen TK.
  Title
Protein regions important for plasminogen activation and inactivation of alpha2-antiplasmin in the surface protease Pla of Yersinia pestis.
  Journal
Mol. Microbiol. 40 (2001) 1097-111.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
101028-08-4

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