KEGG   ENZYME: 3.4.23.50Help
Entry
EC 3.4.23.50                Enzyme                                 

Name
human endogenous retrovirus K endopeptidase;
human endogenous retrovirus K10 endopeptidase;
endogenous retrovirus HERV-K10 putative protease;
human endogenous retrovirus K retropepsin;
HERV K10 endopeptidase;
HERV K10 retropepsin;
HERV-K PR;
HERV-K protease;
HERV-K113 protease;
human endogenous retrovirus K113 protease;
human retrovirus K10 retropepsin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY!PIVQ- cleavage site.
Comment
In peptidase family A2.
History
EC 3.4.23.50 created 2009
Reference
1  [PMID:9860826]
  Authors
Towler EM, Gulnik SV, Bhat TN, Xie D, Gustschina E, Sumpter TR, Robertson N, Jones C, Sauter M, Mueller-Lantzsch N, Debouck C, Erickson JW
  Title
Functional characterization of the protease of human endogenous retrovirus, K10:  can it complement HIV-1 protease?
  Journal
Biochemistry. 37 (1998) 17137-44.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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