KEGG   ENZYME: 3.4.24.13Help
Entry
EC 3.4.24.13                Enzyme                                 

Name
IgA-specific metalloendopeptidase;
immunoglobulin A1 proteinase;
IgA protease;
IgA1-specific proteinase;
IgA1 protease;
IgA1 proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of Pro!Thr bond in the hinge region of the heavy chain of human IgA
Comment
A 190 kDa enzyme found in several pathogenic species of Streptococcus such as sanguis and pneumoniae. Type example of peptidase family M26. There is also an IgA-specific prolyl endopeptidase of the serine-type (see EC 3.4.21.72, IgA-specific serine endopeptidase)
History
EC 3.4.24.13 created 1984
Orthology
K01390  IgA-specific metalloendopeptidase
Genes
SPN: SP_1154(zmpA)
SPD: SPD_1018(iga)
SPR: spr1042(iga)
SPW: SPCG_1143(iga)
SPX: SPG_1053(igA)
SNE: SPN23F10580(zmpA)
SPV: SPH_1229
SNM: SP70585_1207
SJJ: SPJ_1073
SPP: SPP_1140
SNT: SPT_1181
SNP: SPAP_1059
SNI: INV104_09960(zmpA)
SNV: SPNINV200_10720(zmpA)
SNX: SPNOXC10390(zmpA)
SND: MYY_1183
SPNG: HMPREF1038_01043(iga)
SPNE: SPN034156_01270(zmpA)
SPNU: SPN034183_10390(zmpA)
SPNM: SPN994038_10280(zmpA)
SPNO: SPN994039_10290(zmpA)
SPNN: T308_05505
SSA: SSA_1106(iga)
SOR: SOR_0589
 » show all
Taxonomy
Reference
1  [PMID:6792682]
  Authors
Kornfeld SJ, Plaut AG.
  Title
Secretory immunity and the bacterial IgA proteases.
  Journal
Rev. Infect. Dis. 3 (1981) 521-34.
Reference
2  [PMID:1987065]
  Authors
Gilbert JV, Plaut AG, Wright A.
  Title
Analysis of the immunoglobulin A protease gene of Streptococcus sanguis.
  Journal
Infect. Immun. 59 (1991) 7-17.
  Sequence
[ssa:SSA_1106]
Reference
3  [PMID:3294181]
  Authors
Gilbert JV, Plaut AG, Fishman Y, Wright A.
  Title
Cloning of the gene encoding streptococcal immunoglobulin A protease and its expression in Escherichia coli.
  Journal
Infect. Immun. 56 (1988) 1961-6.
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.13
IUBMB Enzyme Nomenclature: 3.4.24.13
ExPASy - ENZYME nomenclature database: 3.4.24.13
BRENDA, the Enzyme Database: 3.4.24.13
CAS: 72231-73-3

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