KEGG   ENZYME: 3.4.24.16Help
Entry
EC 3.4.24.16                Enzyme                                 

Name
neurolysin;
neurotensin endopeptidase;
endopeptidase 24.16;
endo-oligopeptidase B (proline-endopeptidase)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage in neurotensin: Pro10!Tyr
Comment
No absolute requirement for a prolyl bond: the enzyme acts on some peptides, such as dynorphin 1-8, that do not contain proline, and does not act on some others that do. In peptidase family M3 (thimet oligopeptidase family)
History
EC 3.4.24.16 created 1989
Orthology
K01393  
neurolysin
Genes
HSA: 
57486(NLN)
PTR: 
461840(NLN)
PPS: 
GGO: 
PON: 
MCC: 
MCF: 
MMU: 
75805(Nln)
RNO: 
117041(Nln)
CGE: 
HGL: 
TUP: 
CFA: 
478081(NLN)
AML: 
FCA: 
PTG: 
BTA: 
538650(NLN)
BOM: 
PHD: 
CHX: 
SSC: 
CFR: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
427167(NLN)
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
PSS: 
CMY: 
ACS: 
XTR: 
LCM: 
SPU: 
 » show all
Taxonomy
Reference
1  [PMID:3525564]
  Authors
Checler F, Vincent JP, Kitabgi P.
  Title
Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes.
  Journal
J. Biol. Chem. 261 (1986) 11274-81.
  Organism
Rattus norvegicus
Reference
2  [PMID:3409880]
  Authors
Barelli H, Vincent JP, Checler F.
  Title
Peripheral inactivation of neurotensin. Isolation and characterization of a metallopeptidase from rat ileum.
  Journal
Eur. J. Biochem. 175 (1988) 481-9.
  Organism
Rattus norvegicus
Reference
3  [PMID:2649078]
  Authors
Checler F, Barelli H, Vincent JP.
  Title
Tissue distribution of a novel neurotensin-degrading metallopeptidase. An immunological approach using monospecific polyclonal antibodies.
  Journal
Biochem. J. 257 (1989) 549-54.
  Organism
Rattus norvegicus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
149371-24-4

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