KEGG   ENZYME: 3.4.24.25Help
Entry
EC 3.4.24.25                Enzyme                                 

Name
vibriolysin;
Aeromonas proteolytica neutral proteinase;
aeromonolysin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage of bonds with bulky hydrophobic groups in P2 and P1'. Phe at P1' is the most favoured residue, which distinguished this enzyme from thermolysin
Comment
Thermostable enzyme from Vibrio proteolyticus (formerly Aeromonas proteolytica). Specificity related to, but distinct from, those of thermolysin and bacillolysin [1]. A zinc metallopeptidase in family M4 (thermolysin family). Formerly included in EC 3.4.24.4
History
EC 3.4.24.25 created 1972 as EC 3.4.24.4, part transferred 1992 to EC 3.4.24.25, modified 1997
Orthology
K08604  
vibriolysin
Genes
XSA: 
LAB: 
LCP: 
LGU: 
LEZ: 
GLE_2741(nprV) GLE_2743(nprV)
DTX: 
VCH: 
VCF: 
VCE: 
VCJ: 
VCO: 
VCR: 
VCM: 
VCI: 
VCL: 
VCQ: 
VCS: 
VCX: 
VCZ: 
VVU: 
VVY: 
VVM: 
VVL: 
VPA: 
VPB: 
VPF: 
VPH: 
VHA: 
VCA: 
VEX: 
VSP: 
VS_1267(vsm)
VFU: 
VAN: 
LAG: 
VAU: 
VCY: 
VCT: 
VTU: 
VFL: 
VMI: 
SDN: 
SAZ: 
SBL: 
SBM: 
SBN: 
SBP: 
SBT: 
SBS: 
SBB: 
SHE: 
SHM: 
SHN: 
SWD: 
PSM: 
PIA: 
PPHE: 
PBW: 
PRR: 
MVS: 
MVIS_1898(empA) MVIS_2920(empA)
SAGA: 
LPN: 
LPH: 
LPO: 
LPU: 
LPM: 
LPF: 
LPP: 
LPC: 
LPA: 
LPE: 
LLO: 
LFA: 
TMC: 
PSAL: 
PSLF89_34(lasB)
TIG: 
HCH: 
KKO: 
KGE: 
MME: 
GSN: 
AHA: 
AHY: 
AHD: 
AHR: 
AHP: 
AHJ: 
AHH: 
AHI: 
AVR: 
AMED: 
ASR: 
JAB: 
CPRA: 
RDP: 
MIU: 
MXA: 
MXAN_6106(fibA)
MFU: 
MSD: 
MYM: 
CCX: 
AGE: 
CCRO: 
HOE: 
 » show all
Taxonomy
Reference
1  [PMID:2276]
  Authors
Holmquist B, Vallee BL.
  Title
Esterase activity of zinc neutral proteases.
  Journal
Biochemistry. 15 (1976) 101-7.
Reference
2  [PMID:1012006]
  Authors
Wilkes SH, Prescott JM.
  Title
Aeromonas neutral protease.
  Journal
Methods. Enzymol. 45 (1976) 404-15.
Reference
3  [PMID:7000005]
  Authors
Bayliss ME, Wilkes SH, Prescott JM.
  Title
Aeromonas neutral protease: specificity toward extended substrates.
  Journal
Arch. Biochem. Biophys. 204 (1980) 214-9.
Reference
4  [PMID:3123480]
  Authors
Wilkes SH, Bayliss ME, Prescott JM.
  Title
Critical ionizing groups in Aeromonas neutral protease.
  Journal
J. Biol. Chem. 263 (1988) 1821-5.
Reference
5  [PMID:1551587]
  Authors
David VA, Deutch AH, Sloma A, Pawlyk D, Ally A, Durham DR
  Title
Cloning, sequencing and expression of the gene encoding the extracellular neutral protease, vibriolysin, of Vibrio proteolyticus.
  Journal
Gene. 112 (1992) 107-12.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
69598-88-5

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