KEGG   ENZYME: 3.4.24.26Help
Entry
EC 3.4.24.26                Enzyme                                 

Name
pseudolysin;
Pseudomonas elastase;
Pseudomonas aeruginosa neutral metalloproteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects
Comment
In peptidase family M4 (thermolysin family). From the pathogenic bacteria Pseudomonas aeruginosa and Legionella pneumophila, and causes tissue damage.
History
EC 3.4.24.26 created 1972 as EC 3.4.24.4, part transferred 1992 to EC 3.4.24.26
Orthology
K01399  
pseudolysin
Genes
RHD: 
PAE: 
PA3724(lasB)
PAEV: 
N297_3847(lasB)
PAEI: 
N296_3847(lasB)
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PAEB: 
PDK: 
PSG: 
PRP: 
PAEP: 
PAER: 
PAEM: 
PAEL: 
PAES: 
PAEU: 
BN889_04117(lasB_1)
PAEG: 
PAEC: 
M802_3844(lasB)
PAEO: 
M801_3712(lasB)
SVO: 
LPN: 
LPH: 
LPV_0568(proA) LPV_1911(lasB)
LPO: 
LPO_0533(proA) LPO_1690(lasB) LPO_3312(lasB)
LPU: 
LPM: 
LP6_0458(proA1) LP6_1633(lasB1) LP6_3016(lasB)
LPF: 
LPP: 
LPC: 
LPC_1085(lasB) LPC_2877(proA) LPC_3292(lasB)
LPA: 
lpa_00713(lasB) lpa_02392(lasB) lpa_04362(lasB) lpa_04363(lasB)
LPE: 
LLO: 
LFA: 
LHA: 
TMC: 
TIG: 
CVI: 
CV_0057(lasB)
CFU: 
CARE: 
HOH: 
 » show all
Taxonomy
Reference
1
  Authors
Morihara, K. and Tsuzuki, H.
  Title
Pseudomonas aeruginosa elastase: affinity chromatography and some properties as a metallo-neutral proteinase.
  Journal
Agric. Biol. Chem. 39 (1975) 1123-1128.
Reference
2  [PMID:6767718]
  Authors
Nishino N, Powers JC.
  Title
Pseudomonas aeruginosa elastase. Development of a new substrate, inhibitors, and an affinity ligand.
  Journal
J. Biol. Chem. 255 (1980) 3482-6.
Reference
3  [PMID:3512431]
  Authors
Dreyfus LA, Iglewski BH.
  Title
Purification and characterization of an extracellular protease of Legionella pneumophila.
  Journal
Infect. Immun. 51 (1986) 736-43.
Reference
4  [PMID:2842313]
  Authors
Bever RA, Iglewski BH.
  Title
Molecular characterization and nucleotide sequence of the Pseudomonas aeruginosa elastase structural gene.
  Journal
J. Bacteriol. 170 (1988) 4309-14.
  Sequence
[pae:PA3724]
Reference
5  [PMID:2110146]
  Authors
Black WJ, Quinn FD, Tompkins LS.
  Title
Legionella pneumophila zinc metalloprotease is structurally and functionally homologous to Pseudomonas aeruginosa elastase.
  Journal
J. Bacteriol. 172 (1990) 2608-13.
  Sequence
[lpn:lpg0467]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
171715-23-4

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