KEGG   ENZYME: 3.4.24.41Help
Entry
EC 3.4.24.41                Enzyme                                 

Name
atrolysin B;
Crotalus atrox metalloendopeptidase b;
hemorrhagic toxin b;
Ht-b
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of His5!Leu, His10!Leu, Ala14!Leu, Tyr16!Leu and Gly23!Phe of insulin B chain; identical to the cleavage of insulin B chain by atrolysin C. Also cleaves !Ser bonds in glucagon
Comment
From the venom of the western diamondback rattlesnake (Crotalus atrox). In peptidase family M12 (astacin family)
History
EC 3.4.24.41 created 1992
Reference
1  [PMID:210790]
  Authors
Bjarnason JB, Tu AT.
  Title
Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e.
  Journal
Biochemistry. 17 (1978) 3395-404.
Reference
2  [PMID:3060135]
  Authors
Bjarnason JB, Hamilton D, Fox JW.
  Title
Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom.
  Journal
Biol. Chem. Hoppe. Seyler. 369 Suppl (1988) 121-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
172306-48-8

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