KEGG   ENZYME: 3.4.24.57Help
Entry
EC 3.4.24.57                Enzyme                                 

Name
O-sialoglycoprotein endopeptidase;
glycoprotease;
glycophorin A proteinase;
glycoproteinase;
sialoglycoprotease;
sialoglycoproteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of O-sialoglycoproteins; cleaves -Arg31!Asp- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated
Comment
An enzyme secreted by the bacterium Pasteurella haemolytica. Inhibited by EDTA (100 mM) and 1,10-phenanthroline. Type example of peptidase family M22
History
EC 3.4.24.57 created 1993
Reference
1  [PMID:1885539]
  Authors
Abdullah KM, Lo RY, Mellors A.
  Title
Cloning, nucleotide sequence, and expression of the Pasteurella haemolytica A1 glycoprotease gene.
  Journal
J. Bacteriol. 173 (1991) 5597-603.
  Sequence
[up:P36175]
Reference
2  [PMID:1729196]
  Authors
Abdullah KM, Udoh EA, Shewen PE, Mellors A.
  Title
A neutral glycoprotease of Pasteurella haemolytica A1 specifically cleaves O-sialoglycoproteins.
  Journal
Infect. Immun. 60 (1992) 56-62.
Reference
3  [PMID:1371528]
  Authors
Sutherland DR, Abdullah KM, Cyopick P, Mellors A.
  Title
Cleavage of the cell-surface O-sialoglycoproteins CD34, CD43, CD44, and CD45 by a novel glycoprotease from Pasteurella haemolytica.
  Journal
J. Immunol. 148 (1992) 1458-64.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
129430-53-1

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