KEGG   ENZYME: 3.4.24.62Help
Entry
EC 3.4.24.62                Enzyme                                 

Name
magnolysin;
bovine neurosecretory granule protease cleaving pro-oxytocin/neurophysin;
pro-oxytocin/neurophysin convertase;
prooxyphysin proteinase;
pro-oxytocin convertase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of polypeptides with Arg or Lys in P1 and P2, e.g. to hydrolyse pro-oxytocin at -Lys-Arg!Ala-Val-. The specificity further depends on the organization of a beta-turn-alpha-helix of nine or more residues containing the paired basic amino acids near the centre [3]
Comment
An endopeptidase of 58 kDa known from bovine pituitary neurosecretory granules and bovine and human corpus luteum [4,5]. Inhibited by EDTA [1]
History
EC 3.4.24.62 created 1995
Reference
1  [PMID:2825769]
  Authors
Clamagirand C, Creminon C, Fahy C, Boussetta H, Cohen P.
  Title
Partial purification and functional properties of an endoprotease from bovine neurosecretory granules cleaving proocytocin/neurophysin peptides at the basic amino acid doublet.
  Journal
Biochemistry. 26 (1987) 6018-23.
Reference
2  [PMID:3042797]
  Authors
Creminon C, Rholam M, Boussetta H, Marrakchi N, Cohen P.
  Title
Synthetic peptide substrates as models to study a pro-ocytocin/neurophysin converting enzyme.
  Journal
J. Chromatogr. 440 (1988) 439-48.
Reference
3  [PMID:2674120]
  Authors
Brakch N, Boussetta H, Rholam M, Cohen P.
  Title
Processing endoprotease recognizes a structural feature at the cleavage site of peptide prohormones. The pro-ocytocin/neurophysin model.
  Journal
J. Biol. Chem. 264 (1989) 15912-6.
Reference
4  [PMID:2659078]
  Authors
Plevrakis I, Clamagirand C, Creminon C, Brakch N, Rholam M, Cohen P.
  Title
Proocytocin/neurophysin convertase from bovine neurohypophysis and corpus luteum secretory granules: complete purification, structure-function relationships, and competitive inhibitor.
  Journal
Biochemistry. 28 (1989) 2705-10.
Reference
5  [PMID:7931007]
  Authors
Guillou MD, Camier M, Clamagirand C.
  Title
Evidence for the presence of pro-oxytocin/neurophysin-converting enzyme in the human ovary.
  Journal
J. Endocrinol. 142 (1994) 345-52.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
162875-09-4

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