KEGG   ENZYME: 3.4.24.72Help
Entry
EC 3.4.24.72                Enzyme                                 

Name
fibrolase;
fibrinolytic proteinase;
Agkistrodon contortrix contortrix metalloproteinase;
Agkistrodon contortrix contortrix venom metalloproteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of -Ala14!Leu- in insulin B chain and -Lys413!Leu- in Aalpha-chain of fibrinogen
Comment
A 23-kDa, non-hemorrhagic enzyme from the venom of the southern copperhead snake (Agkistrodon contortix contortix). In peptidase family M12 (astacin family)
History
EC 3.4.24.72 created 1996
Reference
1  [PMID:3232124]
  Authors
Retzios AD, Markland FS Jr.
  Title
A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems.
  Journal
Thromb. Res. 52 (1988) 541-52.
Reference
2  [PMID:1898066]
  Authors
Guan AL, Retzios AD, Henderson GN, Markland FS Jr.
  Title
Purification and characterization of a fibrinolytic enzyme from venom of the southern copperhead snake (Agkistrodon contortrix contortrix).
  Journal
Arch. Biochem. Biophys. 289 (1991) 197-207.
Reference
3  [PMID:1304358]
  Authors
Randolph A, Chamberlain SH, Chu HL, Retzios AD, Markland FS Jr, Masiarz FR.
  Title
Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix contortrix venom.
  Journal
Protein. Sci. 1 (1992) 590-600.
Reference
4  [PMID:7719479]
  Authors
Loayza SL, Trikha M, Markland FS, Riquelme P, Kuo J.
  Title
Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities.
  Journal
J. Chromatogr. B. Biomed. Appl. 662 (1994) 227-43.
Reference
5  [PMID:8085237]
  Authors
Retzios AD, Markland FS.
  Title
Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basiliscus basiliscus: cleavage site specificity towards the alpha-chain of fibrin.
  Journal
Thromb. Res. 74 (1994) 355-67.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
116036-70-5

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