KEGG   ENZYME: 3.4.24.73Help
Entry
EC 3.4.24.73                Enzyme                                 

Name
jararhagin;
HF2-proteinase;
JF1
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of -His10!Leu-, -Ala14!Leu-, -Tyr16!Leu-and -Phe24!Phe- bonds in insulin B chain
Comment
Hemorrhagic endopeptidase from the venom of the jararaca snake (Bothrops jararaca). The 52-kDa enzyme contains a disintegrin domain [3]. In peptidase family M12 (astacin family)
History
EC 3.4.24.73 created 1996
Orthology
K20139  
jararhagin
Reference
1
  Authors
Mandelbaum, F.R., Reichl, A.P. and Assakura, M.T.
  Title
Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca.
  Journal
In: Ohsaka, A., Hayashi, K. and Sawai, Y. (Eds.), Animal, Plant and Microbial Toxins, Plenum Press, New York, 1976, p. 111-121.
Reference
2  [PMID:3810664]
  Authors
Assakura MT, Reichl AP, Mandelbaum FR.
  Title
Comparison of immunological, biochemical and biophysical properties of three hemorrhagic factors isolated from the venom of Bothrops jararaca (jararaca).
  Journal
Toxicon. 24 (1986) 943-6.
Reference
3  [PMID:1385408]
  Authors
Paine MJ, Desmond HP, Theakston RD, Crampton JM.
  Title
Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family.
  Journal
J. Biol. Chem. 267 (1992) 22869-76.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
160477-79-2

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