KEGG   ENZYME: 3.4.24.86Help
Entry
EC 3.4.24.86                Enzyme                                 

Name
ADAM 17 endopeptidase;
tumor necrosis factor alpha-converting enzyme;
TACE
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala!Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumour necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains
Comment
In peptidase family M12. In vivo, the cleavage of tumour necrosis factor alpha precursor releases the soluble, 17-kDa TNFalpha, which induces inflammation.
History
EC 3.4.24.86 created 2003
Orthology
K06059  disintegrin and metalloproteinase domain-containing protein 17
Genes
HSA: 6868(ADAM17)
PTR: 459018(ADAM17)
PPS: 100988650(ADAM17)
GGO: 101152705(ADAM17)
PON: 100439426(ADAM17)
NLE: 100605134(ADAM17)
MCC: 694429(ADAM17)
MCF: 102116784(ADAM17)
CSAB: 103220846(ADAM17)
RRO: 104675213(ADAM17)
RBB: 108516165(ADAM17)
CJC: 100406520(ADAM17)
SBQ: 101049053(ADAM17)
MMU: 11491(Adam17)
RNO: 57027(Adam17)
CGE: 100684971(Adam17)
NGI: 103747629(Adam17)
HGL: 101720924(Adam17)
CCAN: 109695934(Adam17)
OCU: 100101613(ADAM17)
TUP: 102496316(ADAM17)
CFA: 475662(ADAM17)
AML: 100482770(ADAM17)
UMR: 103675912(ADAM17)
ORO: 101378266(ADAM17)
FCA: 101089004(ADAM17)
PTG: 102948618(ADAM17)
AJU: 106982950(ADAM17)
BTA: 517541(ADAM17)
BOM: 102279111(ADAM17)
BIU: 109566404(ADAM17)
PHD: 102319953(ADAM17)
CHX: 102188327(ADAM17)
OAS: 101116815(ADAM17)
SSC: 397343(ADAM17)
CFR: 102508816(ADAM17)
CDK: 105091236(ADAM17)
BACU: 103004501(ADAM17)
LVE: 103086820(ADAM17)
OOR: 101272366(ADAM17)
ECB: 100072496(ADAM17)
EPZ: 103543937 103560849(ADAM17)
EAI: 106847480(ADAM17)
MYB: 102256292(ADAM17)
MYD: 102767398(ADAM17)
HAI: 109386655(ADAM17)
RSS: 109460495(ADAM17)
PALE: 102894565(ADAM17)
LAV: 100663807(ADAM17)
TMU: 101350544
MDO: 100032069(ADAM17)
SHR: 100926795(ADAM17)
OAA: 100086345(ADAM17)
GGA: 421931(ADAM17)
MGP: 100549409(ADAM17)
CJO: 107312200(ADAM17)
APLA: 101794295(ADAM17)
ACYG: 106030708(ADAM17)
TGU: 100225922(ADAM17)
GFR: 102034165(ADAM17)
FAB: 101814343(ADAM17)
PHI: 102106429(ADAM17)
PMAJ: 107201529(ADAM17)
CCW: 104685448(ADAM17)
FPG: 101924106(ADAM17)
FCH: 102055911(ADAM17)
CLV: 102098173(ADAM17)
EGZ: 104127159(ADAM17)
AAM: 106494759(ADAM17)
ASN: 102373202(ADAM17)
AMJ: 102560812(ADAM17)
PSS: 102454376(ADAM17)
CMY: 102933390(ADAM17)
CPIC: 101938160(ADAM17)
ACS: 100563907(adam17)
PVT: 110080585(ADAM17)
PBI: 103060091(ADAM17)
GJA: 107112820(ADAM17)
XLA: 108718238(adam17.S) 733430(adam17.L)
XTR: 100492947(adam17)
NPR: 108789869(ADAM17)
DRE: 324142(adam17a) 560657(adam17b)
IPU: 108257789 108270063(Adam17)
TRU: 101063716(adam17) 101075639
LCO: 104922135(adam17) 104938532
NCC: 104953609(adam17)
XMA: 102222153 102227287(adam17)
PRET: 103457157(adam17) 103458871
NFU: 107377926 107392286(adam17)
CSEM: 103377555(adam17) 103381366
LCF: 108888136(adam17) 108891569
HCQ: 109526133(adam17) 109531720
BPEC: 110155414(adam17) 110164254
ELS: 105016077(adam17) 105017805
SFM: 108921884(adam17)
LCM: 102367618(ADAM17)
CMK: 103187122(adam17)
CIN: 100175230
SPU: 585715
APLC: 110985040
SKO: 102803736
DME: Dmel_CG7908(Tace)
DSI: Dsimw501_GD21492(Dsim_GD21492)
MDE: 101891592
AAG: 5563722
AME: 551599
BIM: 100745543
BTER: 100645870
SOC: 105197464
AEC: 105143101
ACEP: 105623272
PBAR: 105427116
HST: 105184135
LHU: 105669279
PGC: 109861730
NVI: 100119121
TCA: 663540
DPA: 109537991
NVL: 108563900
BMOR: 101742406
PRAP: 111003508
API: 100158671
DNX: 107167450
ZNE: 110836194
FCD: 110845600
CEL: CELE_ZK154.7(adm-4)
CBR: CBG16796(Cbr-adm-4)
TSP: Tsp_02601
OBI: 106881514
SHX: MS3_01883
EPA: 110250562
ADF: 107358831
HMG: 100210793
 » show all
Taxonomy
Reference
1  [PMID:11733179]
  Authors
Black RA.
  Title
Tumor necrosis factor-alpha converting enzyme.
  Journal
Int. J. Biochem. Cell. Biol. 34 (2002) 1-5.
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.86
IUBMB Enzyme Nomenclature: 3.4.24.86
ExPASy - ENZYME nomenclature database: 3.4.24.86
BRENDA, the Enzyme Database: 3.4.24.86
CAS: 151769-16-3

DBGET integrated database retrieval system