KEGG   ENZYME: 3.4.24.86Help
Entry
EC 3.4.24.86                Enzyme                                 

Name
ADAM 17 endopeptidase;
tumor necrosis factor alpha-converting enzyme;
TACE
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala!Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumour necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains
Comment
In peptidase family M12. In vivo, the cleavage of tumour necrosis factor alpha precursor releases the soluble, 17-kDa TNFalpha, which induces inflammation.
History
EC 3.4.24.86 created 2003
Orthology
K06059  
disintegrin and metalloproteinase domain-containing protein 17
Genes
HSA: 
6868(ADAM17)
PTR: 
459018(ADAM17)
PPS: 
100988650(ADAM17)
GGO: 
101152705(ADAM17)
PON: 
100439426(ADAM17)
NLE: 
100605134(ADAM17)
MCC: 
694429(ADAM17)
MCF: 
102116784(ADAM17)
CSAB: 
103220846(ADAM17)
RRO: 
104675213(ADAM17)
RBB: 
108516165(ADAM17)
CJC: 
100406520(ADAM17)
SBQ: 
101049053(ADAM17)
MMU: 
11491(Adam17)
RNO: 
57027(Adam17)
CGE: 
100684971(Adam17)
NGI: 
103747629(Adam17)
HGL: 
101720924(Adam17)
CCAN: 
109695934(Adam17)
OCU: 
100101613(ADAM17)
TUP: 
102496316(ADAM17)
CFA: 
475662(ADAM17)
AML: 
100482770(ADAM17)
UMR: 
103675912(ADAM17)
FCA: 
101089004(ADAM17)
PTG: 
102948618(ADAM17)
AJU: 
106982950(ADAM17)
BTA: 
517541(ADAM17)
BOM: 
102279111(ADAM17)
BIU: 
109566404(ADAM17)
PHD: 
102319953(ADAM17)
CHX: 
102188327(ADAM17)
OAS: 
101116815(ADAM17)
SSC: 
397343(ADAM17)
CFR: 
102508816(ADAM17)
CDK: 
105091236(ADAM17)
BACU: 
103004501(ADAM17)
LVE: 
103086820(ADAM17)
ECB: 
100072496(ADAM17)
EPZ: 
EAI: 
106847480(ADAM17)
MYB: 
102256292(ADAM17)
MYD: 
102767398(ADAM17)
HAI: 
109386655(ADAM17)
RSS: 
109460495(ADAM17)
PALE: 
102894565(ADAM17)
LAV: 
100663807(ADAM17)
MDO: 
100032069(ADAM17)
SHR: 
100926795(ADAM17)
OAA: 
100086345(ADAM17)
GGA: 
421931(ADAM17)
MGP: 
100549409(ADAM17)
CJO: 
107312200(ADAM17)
APLA: 
101794295(ADAM17)
ACYG: 
106030708(ADAM17)
TGU: 
100225922(ADAM17)
GFR: 
102034165(ADAM17)
FAB: 
101814343(ADAM17)
PHI: 
102106429(ADAM17)
PMAJ: 
107201529(ADAM17)
CCW: 
104685448(ADAM17)
FPG: 
101924106(ADAM17)
FCH: 
102055911(ADAM17)
CLV: 
102098173(ADAM17)
AAM: 
106494759(ADAM17)
ASN: 
102373202(ADAM17)
AMJ: 
102560812(ADAM17)
PSS: 
102454376(ADAM17)
CMY: 
102933390(ADAM17)
CPIC: 
101938160(ADAM17)
ACS: 
100563907(adam17)
PVT: 
110080585(ADAM17)
PBI: 
103060091(ADAM17)
GJA: 
107112820(ADAM17)
XLA: 
108718238(adam17.S) 733430(adam17.L)
XTR: 
100492947(adam17)
NPR: 
108789869(ADAM17)
DRE: 
324142(adam17a) 560657(adam17b)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
104953609(adam17)
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
108921884(adam17)
LCM: 
102367618(ADAM17)
CMK: 
103187122(adam17)
BFO: 
CIN: 
SPU: 
APLC: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD21492(Dsim_GD21492)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
CQU: 
AME: 
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
API: 
DNX: 
PHU: 
FCD: 
DPX: 
ISC: 
CEL: 
CBR: 
CBG16796(Cbr-adm-4)
NAI: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
MYI: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
EPA: 
ADF: 
HMG: 
TAD: 
AQU: 
MBR: 
SRE: 
 » show all
Taxonomy
Reference
1  [PMID:11733179]
  Authors
Black RA.
  Title
Tumor necrosis factor-alpha converting enzyme.
  Journal
Int. J. Biochem. Cell. Biol. 34 (2002) 1-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
151769-16-3

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