KEGG   ENZYME: 3.5.1.109Help
Entry
EC 3.5.1.109                Enzyme                                 

Name
sphingomyelin deacylase;
SM deacylase;
GcSM deacylase;
glucosylceramide sphingomyelin deacylase;
sphingomyelin glucosylceramide deacylase;
SM glucosylceramide GCer deacylase;
SM-GCer deacylase;
SMGCer deacylase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
N-acyl-sphingosylphosphorylcholine amidohydrolase
Reaction(IUBMB)
(1) an N-acyl-sphingosylphosphorylcholine + H2O = a fatty acid + sphingosylphosphorylcholine;
(2) a D-glucosyl-N-acylsphingosine + H2O = a fatty acid + D-glucosyl-sphingosine
Substrate
N-acyl-sphingosylphosphorylcholine;
H2O [CPD:C00001];
D-glucosyl-N-acylsphingosine [CPD:C01190]
Product
fatty acid [CPD:C00162];
sphingosylphosphorylcholine;
D-glucosyl-sphingosine
Comment
The enzyme is involved in the sphingolipid metabolism in the epidermis.
History
EC 3.5.1.109 created 2011
Reference
1  [PMID:10951276]
  Authors
Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G
  Title
High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis.
  Journal
J. Invest. Dermatol. 115 (2000) 406-13.
Reference
2  [PMID:10970788]
  Authors
Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G
  Title
The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide  sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide.
  Journal
Biochem. J. 350 Pt 3 (2000) 747-56.
Reference
3  [PMID:12649340]
  Authors
Ishibashi M, Arikawa J, Okamoto R, Kawashima M, Takagi Y, Ohguchi K, Imokawa G
  Title
Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis.
  Journal
Lab. Invest. 83 (2003) 397-408.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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