KEGG   ENZYME: 3.5.1.111Help
Entry
EC 3.5.1.111                Enzyme                                 

Name
2-oxoglutaramate amidase;
omega-amidase (ambiguous)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
5-amino-2,5-dioxopentanoate amidohydrolase
Reaction(IUBMB)
2-oxoglutaramate + H2O = 2-oxoglutarate + ammonia [RN:R00269]
Reaction(KEGG)
Substrate
2-oxoglutaramate [CPD:C00940];
H2O [CPD:C00001]
Product
2-oxoglutarate [CPD:C00026];
ammonia [CPD:C00014]
Comment
The enzyme, which is highly specific for its substrate, participates in the nicotine degradation pathway of several Gram-positive bacteria.
History
EC 3.5.1.111 created 2012
Reference
1  [PMID:21288482]
  Authors
Cobzaru C, Ganas P, Mihasan M, Schleberger P, Brandsch R
  Title
Homologous gene clusters of nicotine catabolism, including a new omega-amidase for alpha-ketoglutaramate, in species of three genera of Gram-positive bacteria.
  Journal
Res. Microbiol. 162 (2011) 285-91.
  Sequence
[up:Q93NG1]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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