KEGG   ENZYME: 3.5.1.113Help
Entry
EC 3.5.1.113                Enzyme                                 

Name
2'''-acetyl-6'''-hydroxyneomycin C deacetylase;
neoL (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
2'''-acetyl-6'''-hydroxyneomycin C hydrolase (acetate-forming)
Reaction(IUBMB)
2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C + H2O = 6'''-deamino-6'''-hydroxyneomycin C + acetate [RN:R08901]
Reaction(KEGG)
Substrate
2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C;
H2O [CPD:C00001]
Product
6'''-deamino-6'''-hydroxyneomycin C [CPD:C17588];
acetate [CPD:C00033]
Comment
Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. The enzyme from the bacterium Streptomyces fradiae also catalyses EC 3.5.1.112, 2'-N-acetylparomamine deacetylase.
History
EC 3.5.1.113 created 2012
Pathway
Butirosin and neomycin biosynthesis
Biosynthesis of secondary metabolites
Orthology
K17078  
2'-N-acetylparomamine deacetylase / 2'''-acetyl-6'''-hydroxyneomycin deacetylase
Reference
1  [PMID:18311744]
  Authors
Yokoyama K, Yamamoto Y, Kudo F, Eguchi T.
  Title
Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function  deacetylase in neomycin biosynthesis.
  Journal
Chembiochem. 9 (2008) 865-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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