KEGG   ENZYME: 3.5.1.29Help
Entry
EC 3.5.1.29                 Enzyme                                 

Name
2-(acetamidomethylene)succinate hydrolase;
alpha-(N-acetylaminomethylene)succinic acid hydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)
Reaction(IUBMB)
2-(acetamidomethylene)succinate + 2 H2O = acetate + succinate semialdehyde + NH3 + CO2 [RN:R01649]
Reaction(KEGG)
R01649;
(other) R06134
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Substrate
2-(acetamidomethylene)succinate [CPD:C01215];
H2O [CPD:C00001]
Product
acetate [CPD:C00033];
succinate semialdehyde [CPD:C00232];
NH3 [CPD:C00014];
CO2 [CPD:C00011]
Comment
Involved in the degradation of pyridoxin in Pseudomonas.
History
EC 3.5.1.29 created 1972
Pathway
Vitamin B6 metabolism
Microbial metabolism in diverse environments
Orthology
K18614  
2-(acetamidomethylene)succinate hydrolase
Genes
MLO: 
MAM: 
Taxonomy
Reference
1  [PMID:3972793]
  Authors
Huynh MS, Snell EE.
  Title
Enzymes of vitamin B6 degradation. Purification and properties of two N-acetylamidohydrolases.
  Journal
J. Biol. Chem. 260 (1985) 2379-83.
Reference
2  [PMID:5769993]
  Authors
Nyns EJ, Zach D, Snell EE.
  Title
The bacterial oxidation of vitamin B6. 8. Enzymatic breakdown of alpha-(N-acetylaminomethylene) succinic acid.
  Journal
J. Biol. Chem. 244 (1969) 2601-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
37289-09-1

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