KEGG   ENZYME: 3.5.1.43Help
Entry
EC 3.5.1.43                 Enzyme                                 

Name
peptidyl-glutaminase;
peptidoglutaminase I;
peptideglutaminase;
peptidoglutaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
peptidyl-L-glutamine amidohydrolase
Reaction(IUBMB)
alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3 [RN:R04341]
Reaction(KEGG)
R04341;
(other) R06134
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Substrate
alpha-N-peptidyl-L-glutamine [CPD:C03905];
H2O [CPD:C00001]
Product
alpha-N-peptidyl-L-glutamate [CPD:C03904];
NH3 [CPD:C00014]
Comment
Specific for the hydrolysis of the gamma-amide of glutamine substituted at the alpha-amino group, e.g., glycyl-L-glutamine, N-acetyl-L-glutamine and L-leucylglycyl-L-glutamine.
Reference
1  [PMID:4928623]
  Authors
Kikuchi M, Hayashida H, Nakano E, Sakaguchi K.
  Title
Peptidoglutaminase. Enzymes for selective deamidation of gamma-amide of peptide-bound glutamine.
  Journal
Biochemistry. 10 (1971) 1222-9.
  Organism
Bacillus circulans
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37228-70-9

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