KEGG   ENZYME: 3.5.1.89Help
Entry
EC 3.5.1.89                 Enzyme                                 

Name
N-acetylglucosaminylphosphatidylinositol deacetylase;
N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase;
N-acetylglucosaminylphosphatidylinositol de-N-acetylase;
GlcNAc-PI de-N-acetylase;
GlcNAc-PI deacetylase;
acetylglucosaminylphosphatidylinositol deacetylase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase
Reaction(IUBMB)
6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate [RN:R03482 R05917]
Reaction(KEGG)
Substrate
6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [CPD:C01288];
H2O [CPD:C00001]
Product
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [CPD:C04248];
acetate [CPD:C00033]
Comment
Involved in the second step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes. The enzyme appears to be composed of a single subunit (PIG-L in mammalian cells and GPI12 in yeast). In some species, the long-chain sn-1-acyl group of the phosphatidyl group is replaced by a long-chain alkyl or alk-1-enyl group.
History
EC 3.5.1.89 created 1992 as EC 3.1.1.69, transferred 2002 to EC 3.5.1.89, modified 2002
Pathway
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
Metabolic pathways
Orthology
K03434  
N-acetylglucosaminylphosphatidylinositol deacetylase
Genes
HSA: 
9487(PIGL)
PTR: 
468371(PIGL)
PPS: 
100986317(PIGL)
GGO: 
101144089(PIGL)
PON: 
100450550(PIGL)
MCC: 
696605(PIGL)
MCF: 
102118394(PIGL)
MMU: 
327942(Pigl)
RNO: 
192263(Pigl)
CGE: 
HGL: 
101703262(Pigl)
TUP: 
102486610(PIGL)
CFA: 
479514(PIGL)
AML: 
FCA: 
101095055(PIGL)
PTG: 
102950977(PIGL)
BTA: 
507080(PIGL)
BOM: 
102267257(PIGL)
PHD: 
102331893(PIGL)
CHX: 
102178568(PIGL)
SSC: 
100523821(PIGL)
CFR: 
102516594(PIGL)
ECB: 
100073146(PIGL)
MYB: 
102250124(PIGL)
MYD: 
102766905(PIGL)
PALE: 
102893644(PIGL)
MDO: 
SHR: 
OAA: 
GGA: 
417600(PIGL)
MGP: 
TGU: 
100218498(PIGL)
FAB: 
101819705(PIGL)
PHI: 
102109608(PIGL)
APLA: 
101805021(PIGL)
FPG: 
101912638(PIGL)
FCH: 
102055774(PIGL)
CLV: 
102083477(PIGL)
ASN: 
102367899(PIGL)
PSS: 
102460170(PIGL)
CMY: 
102936569(PIGL)
XTR: 
100495759(pigl)
DRE: 
561471(pigl)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102348270(PIGL)
BFO: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
724648(GB19790)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CBR: 
BMY: 
LOA: 
SMM: 
NVE: 
HMG: 
TAD: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0012s03850g(POPTRDRAFT_891844)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os04t0678800-01(Os04g0678800)
OBR: 
BDI: 
SBI: 
SORBI_06g020130(SORBIDRAFT_06g020130) SORBI_06g033040(SORBIDRAFT_06g033040)
ZMA: 
SITA: 
ATR: 
s00001p00033800(AMTR_s00001p00033800)
PPP: 
VCN: 
OLU: 
OTA: 
MIS: 
CVR: 
SCE: 
YMR281W(GPI12)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0C00380(NCAS0C00380)
NDI: 
NDAI_0K00330(NDAI0K00330)
TPF: 
TPHA_0I00280(TPHA0I00280)
TBL: 
TBLA_0B03300(TBLA0B03300)
TDL: 
TDEL_0B00520(TDEL0B00520)
KAF: 
KAFR_0B03960(KAFR0B03960)
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CaO19.12368(GPI12) CaO19.4903(GPI12)
CTP: 
CDU: 
COT: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
TRE: 
SSL: 
BFU: 
ANI: 
NFI: 
AFM: 
AOR: 
AOR_1_672094(AO090120000381)
ANG: 
ANI_1_910124(An14g06640)
AFV: 
ACT: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
PPL: 
LBC: 
MPR: 
CCI: 
SCM: 
UMA: 
MGL: 
ECU: 
EIN: 
EHE: 
NCE: 
DDI: 
DPP: 
DFA: 
DFA_12225(pigL)
EHI: 
EHI_015270(52.t00009)
EDI: 
ACAN: 
PFH: 
TAN: 
TPV: 
BBO: 
BBOV_III007080(17.m07624)
BEQ: 
TGO: 
TET: 
PTM: 
PTI: 
TPS: 
PIF: 
NGD: 
GTT: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:2525555]
  Authors
Doering TL, Masterson WJ, Englund PT, Hart GW.
  Title
Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine.
  Journal
J. Biol. Chem. 264 (1989) 11168-73.
  Organism
Trypanosoma brucei
Reference
2  [PMID:9188481]
  Authors
Nakamura N, Inoue N, Watanabe R, Takahashi M, Takeda J, Stevens VL, Kinoshita T.
  Title
Expression cloning of PIG-L, a candidate N-acetylglucosaminyl-phosphatidylinositol deacetylase.
  Journal
J. Biol. Chem. 272 (1997) 15834-40.
  Organism
Rattus norvegicus
  Sequence
[rno:192263]
Reference
3  [PMID:10085243]
  Authors
Watanabe R, Ohishi K, Maeda Y, Nakamura N, Kinoshita T.
  Title
Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminylphosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis.
  Journal
Biochem. J. 339 ( Pt 1) (1999) 185-92.
  Organism
Saccharomyces cerevisiae, Rattus norvegicus, Homo sapiens
  Sequence
[sce:YMR281W] [rno:192263] [hsa:9487]
Reference
4  [PMID:11432820]
  Authors
Smith TK, Crossman A, Borissow CN, Paterson MJ, Dix A, Brimacombe JS, Ferguson MA.
  Title
Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors.
  Journal
EMBO. J. 20 (2001) 3322-32.
  Organism
Homo sapiens, Trypanosoma brucei
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
122191-30-4

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