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Entry
EC 3.5.1.90                 Enzyme                                 

Name
adenosylcobinamide hydrolase;
CbiZ;
AdoCbi amidohydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
adenosylcobinamide amidohydrolase
Reaction(IUBMB)
adenosylcobinamide + H2O = adenosylcobyric acid + (R)-1-aminopropan-2-ol [RN:R05226]
Reaction(KEGG)
Substrate
adenosylcobinamide [CPD:C06508];
H2O [CPD:C00001]
Product
adenosylcobyric acid [CPD:C06507];
(R)-1-aminopropan-2-ol [CPD:C03194]
Comment
Involved in the salvage pathway of cobinamide in archaea. Archaea convert adenosylcobinamide (AdoCbi) into adenosylcobinamide phosphate (AdoCbi-P) in two steps. First, the amidohydrolase activity of CbiZ cleaves off the aminopropanol moiety of AdoCbi yielding adenosylcobyric acid (AdoCby); second, AdoCby is converted into AdoCbi-P by the action of EC 6.3.1.10, adenosylcobinamide-phosphate synthase (CbiB).
History
EC 3.5.1.90 created 2004
Pathway
Porphyrin and chlorophyll metabolism
Metabolic pathways
Orthology
K08260  
adenosylcobinamide hydrolase
Genes
MAC: 
MBA: 
MBW: 
MBAR: 
MMA: 
MMAZ: 
MMJ: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MHOR: 
MBU: 
MEV: 
MZH: 
MHU: 
MLA: 
MEM: 
MBG: 
MEMA: 
MPI: 
MBN: 
MFO: 
MPL: 
MPD: 
MCP_2916(cbiZ)
MEZ: 
RCI: 
AFU: 
AFG: 
AVE: 
AST: 
FPL: 
GAC: 
GAH: 
HAL: 
HSL: 
OE_3261F(cbiZ)
HDL: 
HHB: 
Hhub_2918(cbiZ)
HMA: 
HHI: 
HHN: 
HAB: 
NPH: 
NP_5300A(cbiZ)
NMO: 
Nmlp_2452(cbiZ)
HUT: 
HMU: 
HJE: 
HSU: 
HSF: 
HWA: 
HQ_1406A(cbiZ)
HWC: 
Hqrw_1482(cbiZ)
HLA: 
HVO: 
HVO_0592(cbiZ)
HME: 
HFX_0579(cbiZ)
HGI: 
HBO: 
HTU: 
NMG: 
HXA: 
NAT: 
NPE: 
NGE: 
HRU: 
NOU: 
HLR: 
HALH: 
HTSR_1763(cbiZ)
FAC: 
PHO: 
PH0814(PH0814)
PAB: 
PFU: 
PFI: 
PYN: 
PYA: 
PYC: 
TKO: 
TON: 
TGA: 
TGAM_0516(cbiZ)
TBA: 
THE: 
THA: 
THM: 
TLT: 
THS: 
TNU: 
TEU: 
TGY: 
THV: 
TCH: 
PPAC: 
 » show all
Taxonomy
Reference
1  [PMID:14990804]
  Authors
Woodson JD, Escalante-Semerena JC.
  Title
CbiZ, an amidohydrolase enzyme required for salvaging the coenzyme B12 precursor cobinamide in archaea.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 3591-6.
  Sequence
[mma:MM_0173] [hal:VNG_1583C]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
905988-16-1

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